β-Secretase Inhibitor IV
Modify Date: 2025-08-25 22:19:00
β-Secretase Inhibitor IV structure
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Common Name | β-Secretase Inhibitor IV | ||
|---|---|---|---|---|
| CAS Number | 797035-11-1 | Molecular Weight | 578.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H38N4O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of β-Secretase Inhibitor IVβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. |
| Name | BETA-SECRETASE INHIBITOR IV |
|---|
| Description | β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. |
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| Related Catalog | |
| Target |
IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1] |
| In Vitro | In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1]. |
| References |
| Molecular Formula | C31H38N4O5S |
|---|---|
| Molecular Weight | 578.72 |
| InChIKey | VPNIQGRFZCTBEZ-SPTGULJVSA-N |
| SMILES | CC(NC(=O)c1cc(C(=O)NC(Cc2ccccc2)C(O)CNC2CC2)cc(N(C)S(C)(=O)=O)c1)c1ccccc1 |