AS 1269574
Modify Date: 2024-01-12 18:55:15
AS 1269574 structure
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Common Name | AS 1269574 | ||
|---|---|---|---|---|
| CAS Number | 330981-72-1 | Molecular Weight | 308.174 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 386.9±42.0 °C at 760 mmHg | |
| Molecular Formula | C13H14BrN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 187.8±27.9 °C | |
Use of AS 1269574AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2]. |
| Name | 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol |
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| Synonym | More Synonyms |
| Description | AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2]. |
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| Related Catalog | |
| Target |
TRPA1 GPR119 |
| In Vivo | AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration[1]. Animal Model: Eight-week-old ICR mice[1] Dosage: 100 mg/kg Administration: P.o. Result: Sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration. Similarly, plasma insulin AUC0-2h was significantly higher in the mice. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 386.9±42.0 °C at 760 mmHg |
| Molecular Formula | C13H14BrN3O |
| Molecular Weight | 308.174 |
| Flash Point | 187.8±27.9 °C |
| Exact Mass | 307.032013 |
| PSA | 58.04000 |
| LogP | 2.32 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.648 |
| Storage condition | -20℃ |
|
~81%
AS 1269574 CAS#:330981-72-1 |
| Literature: Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 7 p. 2369 - 2375 |
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AS 1269574 CAS#:330981-72-1 |
| Literature: Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 7 p. 2369 - 2375 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| hms1581i01 |
| Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]- |
| 2-{[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino}ethanol |
| AS-1269574 |