1,4-DPCA

Modify Date: 2024-01-08 09:05:32

1,4-DPCA structure	Common Name	1,4-DPCA
	CAS Number	331830-20-7	Molecular Weight	240.214
	Density	1.5±0.1 g/cm3	Boiling Point	474.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₈N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	240.8±28.7 °C

Use of 1,4-DPCA

1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2].

Name	4-oxo-1,4-dihydro-[1,10]phenanthroline-3-carboxylic acid
Synonym	More Synonyms

Description	1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 2.4 µM (Collagen hydroxylation); 60 μM (Factor inhibiting HIF (FIH))[2]
In Vitro	1,4-DPCA (24 hours) treatment specifically increases the expression of multiple target genes, including the proangiogenic target genes Vegfa and Hmox1 and proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1 in mouse B6 cells[1]. 1,4-DPCA treatment significantly reduces the colony sizes of T4-2 (10 μM 1,4-DPCA) and ZR-75-1 cells (20 μM 1,4-DPCA). 1,4-DPCA-treated T4-2 cells form polarized spheroids in 3D culture. 1,4-DPCA treatment significantly reduces invasive branches in DA-MB-157 (20 μM 1,4-DPCA) and MDA-MB-231 (10 μM 1,4-DPCA) cells.1,4-DPCA inhibits the proliferation of T4-2, ZR-75-1, MDA-MB-157 and MDA-MB-231 cells[3].
In Vivo	1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition[2].
References	[1]. Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. [2]. Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. [3]. Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1.

Density	1.5±0.1 g/cm3
Boiling Point	474.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₈N₂O₃
Molecular Weight	240.214
Flash Point	240.8±28.7 °C
Exact Mass	240.053497
PSA	83.05000
LogP	3.28
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.727

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,10-phenanthroline-3-carboxylic acid, 4-hydroxy-

T B666 CN NNJ EVQ FQ

1,4-Dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid

1,10-Phenanthroline-3-carboxylic acid, 1,4-dihydro-4-oxo-

4-Hydroxy-1,10-phenanthroline-3-carboxylic acid

T B666 CM FV NNJ EVQ

4-Oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid

4-Oxo-1,4-dihydro-[1,10]phenanthroline-3-carboxylic acid

1,4-dpca

MFCD07357380

DC Chemicals Limited
China
Product Name: 1,4-DPCA
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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1,4-DPCA

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