Hypophyllanthin structure
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Common Name | Hypophyllanthin | ||
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CAS Number | 33676-00-5 | Molecular Weight | 430.491 | |
Density | 1.158 | Boiling Point | 511.1±50.0 °C at 760 mmHg | |
Molecular Formula | C24H30O7 | Melting Point | 129-130℃ | |
MSDS | N/A | Flash Point | 200.8±30.0 °C |
Use of HypophyllanthinHypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. |
Name | (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole |
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Synonym | More Synonyms |
Description | Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2]. |
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Related Catalog | |
Target |
P-gp[2] |
In Vitro | Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1]. |
References |
Density | 1.158 |
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Boiling Point | 511.1±50.0 °C at 760 mmHg |
Melting Point | 129-130℃ |
Molecular Formula | C24H30O7 |
Molecular Weight | 430.491 |
Flash Point | 200.8±30.0 °C |
Exact Mass | 430.199158 |
PSA | 64.61000 |
LogP | 3.77 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.536 |
~% Hypophyllanthin CAS#:33676-00-5 |
Literature: Schneiders, Gail E.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 999 - 1004 |
~% Hypophyllanthin CAS#:33676-00-5 |
Literature: Tetrahedron Letters, , vol. 22, p. 393 - 396 |
(7R,8R,9S)-9-(3,4-Dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxole |
UNII:22ZZ21E33P |
Naphtho[1,2-d]-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7R,8R,9S)- |
Hypophyllanthin |
Hypophyllantin |