Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Hypophyllanthin
  • Price: ¥2900.0/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng



Related CAS#:

33676-00-5

33676-00-5 structure
33676-00-5 structure
  • Name: Hypophyllanthin
  • Chemical Name: (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
  • CAS Number: 33676-00-5
  • Molecular Formula: C24H30O7
  • Molecular Weight: 430.491
  • Catalog: Natural product Lignans
  • Create Date: 2018-12-25 12:42:36
  • Modify Date: 2024-01-02 13:07:31
  • Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].

Name (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
Synonyms (7R,8R,9S)-9-(3,4-Dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxole
UNII:22ZZ21E33P
Naphtho[1,2-d]-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7R,8R,9S)-
Hypophyllanthin
Hypophyllantin
Description Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].
Related Catalog
Target

P-gp[2]

In Vitro Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt[1].
References

[1]. Harikrishnan H, et al. Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways. Inflammation. 2018 Jun;41(3):984-995.

[2]. Sukhaphirom N, et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. J Pharm Pharmacol. 2013 Feb;65(2):292-9.

Density 1.158
Boiling Point 511.1±50.0 °C at 760 mmHg
Melting Point 129-130℃
Molecular Formula C24H30O7
Molecular Weight 430.491
Flash Point 200.8±30.0 °C
Exact Mass 430.199158
PSA 64.61000
LogP 3.77
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.536
Hazard Codes Xn
Risk Phrases R22

~%

33676-00-5 structure

33676-00-5

Literature: Schneiders, Gail E.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 999 - 1004

~%

33676-00-5 structure

33676-00-5

Literature: Tetrahedron Letters, , vol. 22, p. 393 - 396