CAY10550
Modify Date: 2024-01-12 19:14:58
CAY10550 structure
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Common Name | CAY10550 | ||
|---|---|---|---|---|
| CAS Number | 34320-83-7 | Molecular Weight | 281.27 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 445.1±47.0 °C at 760 mmHg | |
| Molecular Formula | C15H11N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 223.0±29.3 °C | |
Use of CAY10550TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1]. |
| Name | 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one |
|---|---|
| Synonym | More Synonyms |
| Description | TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1]. |
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| Related Catalog | |
| Target |
IC50: 3 nM (PrPC in ScN2a and F3 cells)[1] |
| In Vitro | TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 445.1±47.0 °C at 760 mmHg |
| Molecular Formula | C15H11N3O3 |
| Molecular Weight | 281.27 |
| Flash Point | 223.0±29.3 °C |
| Exact Mass | 281.080048 |
| PSA | 78.49000 |
| LogP | 1.92 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.674 |
| HS Code | 2933199090 |
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|
~82%
CAY10550 CAS#:34320-83-7 |
| Literature: Kimata, Ayako; Nakagawa, Hidehiko; Ohyama, Ryo; Fukuuchi, Tomoko; Ohta, Shigeru; Suzuki, Takayoshi; Miyata, Naoki Journal of Medicinal Chemistry, 2007 , vol. 50, # 21 p. 5053 - 5056 |
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~0%
CAY10550 CAS#:34320-83-7 |
| Literature: Azev; Teplyashina Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 9 p. 1091 - 1092 |
| HS Code | 2933199090 |
|---|---|
| Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| TCS PRP INHIBITOR 13 |
| Necrosulfonamide |
| 1-Phenyl-3-p-nitrophenylpyrazolon |
| 3H-Pyrazol-3-one, 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl- |
| 5-(4-Nitrophenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one |