TCS PrP Inhibitor 13

• 常用名: TCS PrP Inhibitor 13
• 英文名: CAY10550
• CAS号: 34320-83-7
• 分子量: 281.27
• 密度: 1.4±0.1 g/cm3
• 沸点: 445.1±47.0 °C at 760 mmHg
• 分子式: C₁₅H₁₁N₃O₃
• 熔点: N/A
• 闪点: 223.0±29.3 °C

TCS PrP Inhibitor 13用途

TCS PrP抑制物13是一种抗朊病毒药物,是一种细胞朊病毒蛋白(PrPC)抑制物。TCS-PrP抑制剂13是一种蛋白酶抗性形式的朊蛋白(PrP-res)积累抑制剂,在ScN2a和F3细胞系中显示出3nm的IC50值。TCS PrP抑制剂13诱导神经鞘瘤细胞凋亡[1]。

TCS PrP Inhibitor 13名称

• 英文名: 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one

TCS PrP Inhibitor 13生物活性

• 描述: TCS PrP抑制物13是一种抗朊病毒药物,是一种细胞朊病毒蛋白(PrPC)抑制物。TCS-PrP抑制剂13是一种蛋白酶抗性形式的朊蛋白(PrP-res)积累抑制剂,在ScN2a和F3细胞系中显示出3nm的IC50值。TCS PrP抑制剂13诱导神经鞘瘤细胞凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
• 靶点实验:

  IC50: 3 nM (PrPC in ScN2a and F3 cells)[1]

• 体外研究: TCS-PrP抑制剂13(0~500μM；神经鞘瘤细胞)显著降低总ERK1/2、pAKT、总FAK、细胞周期蛋白D1、PrPC的水平,并显著增加裂解的caspase-3的表达。TCS PrP抑制剂13(神经鞘瘤细胞)显著减少增殖、Ki67阳性细胞数量和总细胞数量[2]。
• 参考文献:

  [1]. Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056.

  [2]. Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142.

TCS PrP Inhibitor 13物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 445.1±47.0 °C at 760 mmHg
• 分子式: C₁₅H₁₁N₃O₃
• 分子量: 281.27
• 闪点: 223.0±29.3 °C
• 精确质量: 281.080048
• PSA: 78.49000
• LogP: 1.92
• InChIKey: FDAVFKZPGQEGDX-UHFFFAOYSA-N
• SMILES: O=C1CC(c2ccc([N+](=O)[O-])cc2)=NN1c1ccccc1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.674

TCS PrP Inhibitor 13安全信息

• 海关编码: 2933199090

TCS PrP Inhibitor 13海关

• 海关编码: 2933199090
• 中文概述: 2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

TCS PrP Inhibitor 13靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Antiprion activity in Gerstmann-Straussler-Scheinker syndrome infected mouse ScN2a-3-... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1913513

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

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TCS PrP Inhibitor 13英文别名

• TCS PRP INHIBITOR 13
• Necrosulfonamide
• 1-Phenyl-3-p-nitrophenylpyrazolon
• 5-(4-Nitrophenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one