2-Methylsuccinic acid-d6

Modify Date: 2024-01-02 10:08:04

2-Methylsuccinic acid-d6 Structure
2-Methylsuccinic acid-d6 structure
Common Name 2-Methylsuccinic acid-d6
CAS Number 347840-08-8 Molecular Weight 138.15200
Density N/A Boiling Point N/A
Molecular Formula C5H2D6O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-Methylsuccinic acid-d6


2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid[1]. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy[2][3].

 Names

Name 2-methyl-d3-succinic-2,3,3-d3 acid

 2-Methylsuccinic acid-d6 Biological Activity

Description 2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid[1]. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Grosso S, et al. Ethylmalonic encephalopathy: further clinical and neuroradiological characterization. J Neurol. 2002 Oct;249(10):1446-50.  

[3]. Nowaczyk MJ, et al. Ethylmalonic and methylsuccinic aciduria in ethylmalonic encephalopathy arise from abnormal isoleucine metabolism. Metabolism. 1998 Jul47(7):836-9.  

 Chemical & Physical Properties

Molecular Formula C5H2D6O4
Molecular Weight 138.15200
Exact Mass 138.08000
PSA 74.60000
LogP 0.18180