β-Estradiol-6-one 6-(O-carboxymethyloxime)
β-Estradiol-6-one 6-(O-carboxymethyloxime) structure
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Common Name | β-Estradiol-6-one 6-(O-carboxymethyloxime) | ||
|---|---|---|---|---|
| CAS Number | 35048-47-6 | Molecular Weight | 359.416 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 572.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H25NO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 300.1±32.9 °C | |
Use of β-Estradiol-6-one 6-(O-carboxymethyloxime)β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 17β-estradiol 6-O-(carboxymethyl)oxime |
|---|---|
| Synonym | More Synonyms |
| Description | β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 572.6±60.0 °C at 760 mmHg |
| Molecular Formula | C20H25NO5 |
| Molecular Weight | 359.416 |
| Flash Point | 300.1±32.9 °C |
| Exact Mass | 359.173279 |
| PSA | 99.35000 |
| LogP | 2.31 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.680 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
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| Literature: Steroids, , vol. 19, # 4 p. 509 - 518 |
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| Literature: Steroids, , vol. 18, p. 593 - 603 |
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| Literature: Steroids, , vol. 18, p. 593 - 603 |
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| Literature: Steroids, , vol. 30, # 1 p. 85 - 98 |
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| Literature: Steroids, , vol. 21, p. 259 - 283 |
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| Literature: Steroids, , vol. 21, p. 259 - 283 |
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A convenient homogeneous enzyme immunoassay for estradiol detection.
Biotechnol. Appl. Biochem. 58(1) , 75-82, (2011) A convenient homogeneous enzyme immunoassay for estradiol is described. Unlike heterogeneous immunoassays, which require time-consuming separation steps or expensive automated systems, homogeneous imm... |
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Histochemical estrogen receptor assay.
Am. J. Clin. Pathol. 76(3) , 365, (1981)
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Estrogen receptors in human breast cancer. II. Correlation between the histochemical method and biochemical assay.
Virchows Arch.,. B, Cell Pathol. 40(1) , 27-37, (1982) The present study defines criteria for determining the presence of estrogen-receptors in human breast carcinomas demonstrated by a histochemical assay using 17 beta-estradiol-carboxy-methyl-oxim-bovin... |
| ((((17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-ylidene)amino)oxy)acetic acid |
| Beta-Estradiol-6-one 6-(O-carboxymethyloxime) |
| Acetic acid, 2-[[[(6E,17β)-3,17-dihydroxyestra-1(10),2,4-trien-6-ylidene]amino]oxy]- |
| 17β-estradiol 6-O-(carboxymethyl)oxime |
| 1,3,5[10]-ESTRATRIENE-3,17-DIOL-6-ONE 6-[O-CARBOXYMETHYL]OXIME |
| 17beta-estradiol 6-O-(carboxymethyl)oxime |
| β-Estradiol-6-one 6-(O-carboxymethyloxime) |
| SS-ESTRADIOL-6-ONE 6-(O-CARBOXYMETHYLOXIME) |
| 6-keto-1,3,5(10)estratriene-3,17β-diol 6-carboxymethyloxime |
| ({(E)-[(6E,17β)-3,17-Dihydroxyestra-1(10),2,4-trien-6-ylidene]amino}oxy)acetic acid |