β-Estradiol-6-one 6-(O-carboxymethyloxime)

Modify Date: 2025-08-20 10:00:25

β-Estradiol-6-one 6-(O-carboxymethyloxime) Structure
β-Estradiol-6-one 6-(O-carboxymethyloxime) structure
 Common Name β-Estradiol-6-one 6-(O-carboxymethyloxime)
CAS Number 35048-47-6 Molecular Weight 359.416
Density 1.5±0.1 g/cm3 Boiling Point 572.6±60.0 °C at 760 mmHg
Molecular Formula C20H25NO5 Melting Point N/A
MSDS Chinese USA Flash Point 300.1±32.9 °C

 Use of β-Estradiol-6-one 6-(O-carboxymethyloxime)


β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 17β-estradiol 6-O-(carboxymethyl)oxime
Synonym More Synonyms

  Biological Activity

Description β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 572.6±60.0 °C at 760 mmHg
Molecular Formula C20H25NO5
Molecular Weight 359.416
Flash Point 300.1±32.9 °C
Exact Mass 359.173279
PSA 99.35000
LogP 2.31
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.680
InChIKey AWARIMYXKAIIGO-UYGYUSPXSA-N
SMILES CC12CCC3c4ccc(O)cc4C(=NOCC(=O)O)CC3C1CCC2O

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport

 Articles17

More Articles
A convenient homogeneous enzyme immunoassay for estradiol detection.

Biotechnol. Appl. Biochem. 58(1) , 75-82, (2011)

A convenient homogeneous enzyme immunoassay for estradiol is described. Unlike heterogeneous immunoassays, which require time-consuming separation steps or expensive automated systems, homogeneous imm...

Histochemical estrogen receptor assay.

Am. J. Clin. Pathol. 76(3) , 365, (1981)

Estrogen receptors in human breast cancer. II. Correlation between the histochemical method and biochemical assay.

Virchows Arch.,. B, Cell Pathol. 40(1) , 27-37, (1982)

The present study defines criteria for determining the presence of estrogen-receptors in human breast carcinomas demonstrated by a histochemical assay using 17 beta-estradiol-carboxy-methyl-oxim-bovin...

 Synonyms

((((17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-6-ylidene)amino)oxy)acetic acid
Beta-Estradiol-6-one 6-(O-carboxymethyloxime)
Acetic acid, 2-[[[(6E,17β)-3,17-dihydroxyestra-1(10),2,4-trien-6-ylidene]amino]oxy]-
17β-estradiol 6-O-(carboxymethyl)oxime
1,3,5[10]-ESTRATRIENE-3,17-DIOL-6-ONE 6-[O-CARBOXYMETHYL]OXIME
17beta-estradiol 6-O-(carboxymethyl)oxime
β-Estradiol-6-one 6-(O-carboxymethyloxime)
SS-ESTRADIOL-6-ONE 6-(O-CARBOXYMETHYLOXIME)
6-keto-1,3,5(10)estratriene-3,17β-diol 6-carboxymethyloxime
({(E)-[(6E,17β)-3,17-Dihydroxyestra-1(10),2,4-trien-6-ylidene]amino}oxy)acetic acid
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Chemsrc provides CAS#:35048-47-6 MSDS, density, melting point, boiling point, structure, etc. Its name is β-Estradiol-6-one 6-(O-carboxymethyloxime)>> amp version: β-Estradiol-6-one 6-(O-carboxymethyloxime)

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