(2-Iminoimidazolidin-1-yl)acetic acid

Modify Date: 2024-01-02 11:10:25

(2-Iminoimidazolidin-1-yl)acetic acid Structure
(2-Iminoimidazolidin-1-yl)acetic acid structure
Common Name (2-Iminoimidazolidin-1-yl)acetic acid
CAS Number 35404-50-3 Molecular Weight 143.144
Density 1.6±0.1 g/cm3 Boiling Point 278.4±42.0 °C at 760 mmHg
Molecular Formula C5H9N3O2 Melting Point 25-28 °C(lit.)
MSDS Chinese USA Flash Point 122.2±27.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of (2-Iminoimidazolidin-1-yl)acetic acid


Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine crosses membranes, enters the brain, and can be phosphorylated and dephosphorylated by creatine kinases[1].

 Names

Name Cyclocreatine
Synonym More Synonyms

 (2-Iminoimidazolidin-1-yl)acetic acid Biological Activity

Description Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine crosses membranes, enters the brain, and can be phosphorylated and dephosphorylated by creatine kinases[1].
Related Catalog
References

[1]. Salwa A Elgebaly, et al. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion. Expert Rev Cardiovasc Ther. 2019 Sep;17(9):683-697.

[2]. Tyler K Ulland, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017 Aug 10;170(4):649-663.e13.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 278.4±42.0 °C at 760 mmHg
Melting Point 25-28 °C(lit.)
Molecular Formula C5H9N3O2
Molecular Weight 143.144
Flash Point 122.2±27.9 °C
Exact Mass 143.069473
PSA 76.42000
LogP -1.99
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.660
Storage condition -20°C Freezer

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles29

More Articles
Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.

J. Neurosci. 35(14) , 5707-23, (2015)

The distribution of mitochondria within mature, differentiated neurons is clearly adapted to their regional physiological needs and can be perturbed under various pathological conditions, but the func...

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

Neurochem. Res. 39(10) , 1988-96, (2014)

The γ-aminobutyric acid (GABA) transporters (GATs) are key membrane transporter proteins involved in the termination of GABAergic signaling at synapses in the mammalian brain and proposed drug targets...

Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase.

Int. J. Cancer 78(1) , 46-52, (1998)

Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine), an analog of creatine and a substrate for creatine kinase (EC 2.7.3.2), inhibits the stimulated motility of tumor cells which possess creatine kin...

 Synonyms

2-(2-amino-4,5-dihydroimidazol-1-yl)acetic acid
MFCD00134455
(2-Iminoimidazolidin-1-yl)acetic acid
(2-Amino-4,5-dihydro-1H-imidazol-1-yl)acetic acid
1H-Imidazole-1-acetic acid, 2-amino-4,5-dihydro-
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