(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
Modify Date: 2026-07-07 11:27:43
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE structure
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Common Name | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE | ||
|---|---|---|---|---|
| CAS Number | 354811-10-2 | Molecular Weight | 261.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H11N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDEIKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1]. |
| Name | 2-(carbamoylamino)-5-phenylthiophene-3-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1]. |
|---|---|
| Related Catalog | |
| Target |
IKK-2:25 nM (IC50) |
| References |
| Molecular Formula | C12H11N3O2S |
|---|---|
| Molecular Weight | 261.30 |
| Exact Mass | 261.05700 |
| PSA | 128.43000 |
| LogP | 3.47560 |
| InChIKey | PSVUSJKZJQMCSP-UHFFFAOYSA-N |
| SMILES | NC(=O)Nc1sc(-c2ccccc2)cc1C(N)=O |
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Name: ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubat...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301370
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|
Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
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|
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Inhibition of IKK2 in human HUVEC cells assessed as inhibition of TNF-alpha-induced N...
Source: ChEMBL
Target: Inhibitor of nuclear factor kappa-B kinase subunit beta
External Id: CHEMBL5393084
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Name: Inhibition of JAK2 (unknown origin)
Source: ChEMBL
Target: Tyrosine-protein kinase JAK2
External Id: CHEMBL3239499
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|
Name: ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301363
|
|
Name: Inhibition of human IKKbeta using GST-IkappaBalpha as substrate
Source: ChEMBL
Target: Inhibitor of nuclear factor kappa-B kinase subunit beta
External Id: CHEMBL2378059
|
|
Name: Activation of Nrf2 in human HUVEC cells assessed as Nrf2 nuclear translocation at 0.0...
Source: ChEMBL
Target: Nuclear factor erythroid 2-related factor 2
External Id: CHEMBL5393064
|
|
Name: Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent...
Source: ChEMBL
Target: HepG2
External Id: CHEMBL5303715
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|
Name: Inhibition of JAK3 (unknown origin)
Source: ChEMBL
Target: Tyrosine-protein kinase JAK3
External Id: CHEMBL3239500
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| IN1462 |
| HMS3229F13 |
| HMS2043P17 |
| IKK-2 Inhibitor VI |