(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

Modify Date: 2025-08-25 18:15:08

(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE structure	Common Name	(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
	CAS Number	354811-10-2	Molecular Weight	261.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₁N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1].

Name	2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
Synonym	More Synonyms

Description	IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IKK-2:25 nM (IC50)
References	[1]. Baxter A, et, al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22.

Molecular Formula	C₁₂H₁₁N₃O₂S
Molecular Weight	261.30
Exact Mass	261.05700
PSA	128.43000
LogP	3.47560
InChIKey	PSVUSJKZJQMCSP-UHFFFAOYSA-N
SMILES	NC(=O)Nc1sc(-c2ccccc2)cc1C(N)=O

IN1462

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