CP-601927

Modify Date: 2024-01-14 13:45:22

CP-601927 Structure
CP-601927 structure
Common Name CP-601927
CAS Number 357425-02-6 Molecular Weight 227.23
Density N/A Boiling Point N/A
Molecular Formula C12H12F3N Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CP-601927


CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties[1][2].

 Names

Name CP-601927

 CP-601927 Biological Activity

Description CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties[1][2].
Related Catalog
In Vivo CP-601927 (0.125 mg/kg-1.5 mg/kg; i.p.; C57BL/6J male mice) has antidepressant-like activity in animal models[2].
References

[1]. Campion SN, et al. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011;92(4):323-332.

[2]. Mineur YS, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011;22(4):291-299.

 Chemical & Physical Properties

Molecular Formula C12H12F3N
Molecular Weight 227.23
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