3'-sialyllactose

Modify Date: 2024-01-08 11:09:48

3'-sialyllactose Structure
3'-sialyllactose structure
Common Name 3'-sialyllactose
CAS Number 35890-38-1 Molecular Weight 633.55100
Density 1.72 g/cm3 Boiling Point 1132.8ºC at 760 mmHg
Molecular Formula C23H39NO19 Melting Point N/A
MSDS USA Flash Point 638.9ºC

 Use of 3'-sialyllactose


3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2].

 Names

Name (2S,4S,5R,6R)-5-acetamido-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Synonym More Synonyms

 3'-sialyllactose Biological Activity

Description 3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2].
Related Catalog
In Vitro 3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1]. 3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1]. Western Blot Analysis[1] Cell Line: Chondrocytes Concentration: 0, 50, 100 and 250 μM Incubation Time: 24-36 hours Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3,Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.
In Vivo 3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1] Dosage: 10, 50 and 100 mg/kg Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.
References

[1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66.

[2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603.

 Chemical & Physical Properties

Density 1.72 g/cm3
Boiling Point 1132.8ºC at 760 mmHg
Molecular Formula C23H39NO19
Molecular Weight 633.55100
Flash Point 638.9ºC
Exact Mass 633.21200
PSA 342.92000
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes B
RIDADR NONH for all modes of transport
WGK Germany 3

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 Synonyms

N-acetylneuraminoyllactose
3'-Sialyllactose
3'-sialyllactose
3'-Sialyllactose (3'-SL)
32-N-Acetyl-a-neuraminyllactose
3'-N-Acetylneuraminyl-D-lactose
3'-Monosialyllactose
3'-a-Sialyllactose
N-acetylneuraminosyl-D-lactose
3'-Sialyl-D-lactose
a2,3-Sialyllactose
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