2-Methoxy estrone

Modify Date: 2025-08-24 13:11:46

2-Methoxy estrone structure	Common Name	2-Methoxy estrone
	CAS Number	362-08-3	Molecular Weight	300.392
	Density	1.2±0.1 g/cm3	Boiling Point	463.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₄O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	165.9±22.2 °C
	Symbol	GHS08, GHS09	Signal Word	Warning

Use of 2-Methoxy estrone

2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.

Name	2-methoxyestrone
Synonym	More Synonyms

Description	2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
Related Catalog	Natural Products >> Steroids Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Lewis KM, et al. pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone. Steroids. 1979 Nov;34(5):485-99.

Density	1.2±0.1 g/cm3
Boiling Point	463.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₄O₃
Molecular Weight	300.392
Flash Point	165.9±22.2 °C
Exact Mass	300.172546
PSA	46.53000
LogP	3.39
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.576
InChIKey	WHEUWNKSCXYKBU-QPWUGHHJSA-N
SMILES	COc1cc2c(cc1O)CCC1C2CCC2(C)C(=O)CCC12
Storage condition	2-8℃

Symbol	GHS08, GHS09
Signal Word	Warning
Hazard Statements	H351-H410
Precautionary Statements	P273-P281-P501
Hazard Codes	Xn: Harmful;N: Dangerous for the environment;
Risk Phrases	40-50/53
Safety Phrases	22-36-61-60
RIDADR	UN3077 9/PG 3

Precursor 10
CAS#:362-07-2 2-Methoxyestradiol CAS#:83649-26-7 [(8R,9S,13S,14S... CAS#:42979-88-4 3-hydroxy-2-iod... CAS#:124-41-4 Sodium Methylate
CAS#:65932-53-8 3-(2-benzoyl-4-... CAS#:5976-64-7 Estrone 2,3-dim... CAS#:863015-89-8 2-methoxy-3-O-m... CAS#:874920-40-8 2-hydroxy-3-O-m...
CAS#:700369-39-7 2-formyl-3-O-me... CAS#:53-16-7 Estrone
DownStream 5
CAS#:362-06-1 2-hydroxyestrone CAS#:362-07-2 2-Methoxyestradiol CAS#:50394-89-3 2-Hydroxy Ethyn... CAS#:22415-44-7 2-Methoxy-Ethyn...
CAS#:127349-68-2 4-TERT-BUTYLBEN...

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Name: Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL903025

Name: Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL903026

Name: Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL903027

Name: Inhibition of aromatase in human placental microsomes using [1beta-3H]AD as substrate...
Source: ChEMBL
Target: Aromatase
External Id: CHEMBL5241253

Name: Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL903028

Name: Inhibition of recombinant human CYP1B1 expressed in bacterial microsomes co-expressin...
Source: ChEMBL
Target: Cytochrome P450 1B1
External Id: CHEMBL3877873

Name: Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli at 2 uM by s...
Source: ChEMBL
Target: 17-beta-hydroxysteroid dehydrogenase type 1
External Id: CHEMBL1102466

Name: Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL903024

Name: Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cells
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL1102465

Name: Inhibition of His-tagged human 17beta-HSD1 expressed in Escherichia coli by scintilla...
Source: ChEMBL
Target: 17-beta-hydroxysteroid dehydrogenase type 1
External Id: CHEMBL1102464

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2-Methoxy Estrone

2-METHOXYESTRONE

3-hydroxy-2-methoxy-Estra-1,3,5(10)-trien-17-one

(8R,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol

3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one

2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one

2-MeO-E1 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Methoxyestrone?
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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2-Methoxy estrone

Use of 2-Methoxy estrone

Names

2-Methoxy estrone Biological Activity

Chemical & Physical Properties

Safety Information

Precursor & DownStream

Articles2

2-Methoxy estroneBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.