2-hydroxyestrone
2-hydroxyestrone structure
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Common Name | 2-hydroxyestrone | ||
|---|---|---|---|---|
| CAS Number | 362-06-1 | Molecular Weight | 286.36500 | |
| Density | 1.241g/cm3 | Boiling Point | 481.3ºC at 760 mmHg | |
| Molecular Formula | C18H22O3 | Melting Point | 199-201ºC | |
| MSDS | N/A | Flash Point | 259ºC | |
Use of 2-hydroxyestrone2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2-hydroxyestrone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite Estrogen receptor |
| In Vitro | 2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2]. Cell Proliferation Assay[2] Cell Line: Human breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-330 Concentration: 1-1000 nM Incubation Time: 6 days Result: 10 and 100 nM markedly suppressed the growth and proliferation of the cells in the presence of quinalizarin. The tumor cell growth-inhibitory action of the catechol estrogen was neutralized by the presence of 1 nM estradiol. |
| In Vivo | Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and 2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3]. Animal Model: Female and male Sprague-Dawley rats (6 weeks old)[3] Dosage: 2 mg/kg Administration: Administered i.p. Result: Levels of both 2-OHE1 and 2-OHE1 4SR in rats treated with 2-OHE1 were significantly different between the induced and noninduced groups. |
| References |
[1]. H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.241g/cm3 |
|---|---|
| Boiling Point | 481.3ºC at 760 mmHg |
| Melting Point | 199-201ºC |
| Molecular Formula | C18H22O3 |
| Molecular Weight | 286.36500 |
| Flash Point | 259ºC |
| Exact Mass | 286.15700 |
| PSA | 57.53000 |
| LogP | 3.52300 |
| Index of Refraction | 1.609 |
| InChIKey | SWINWPBPEKHUOD-JPVZDGGYSA-N |
| SMILES | CC12CCC3c4cc(O)c(O)cc4CCC3C1CCC2=O |
| Storage condition | 2-8°C |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
|---|---|
| DownStream 3 | |
CAS#:53-16-7
CAS#:53875-00-6
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CAS#:5976-73-8
CAS#:734-32-7
CAS#:362-08-3
CAS#:23463-05-0
CAS#:5976-64-7
CAS#:5976-63-6This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: The compound was tested in vitro for its ability to initiate DNA replication
Source: ChEMBL
Target: Nucleic Acid
External Id: CHEMBL665246
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Name: Major substrate of human cytosolic sulfotransferase SULT1E1
Source: ChEMBL
Target: Sulfotransferase 1E1
External Id: CHEMBL1743309
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 3-Methoxypicolinimidamidehydrochloride |
| 3-O-Methyl 17|A-Estradiol |
| 2-hydroxyestron |
| 2-Hydroxyestrone |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of 2-hydroxyestrone? |
| A: Related downstream products(CAS) of 2-hydroxyestrone: 362-08-3;5976-63-6;5976-64-7. |
| Q: What is the LogP of 2-hydroxyestrone? |
| A: LogP of 2-hydroxyestrone is 3.52300. |
| Q: What is the InChIKey of 2-hydroxyestrone? |
| A: InChIKey of 2-hydroxyestrone is SWINWPBPEKHUOD-JPVZDGGYSA-N. |
| Q: What is the English name of 2-hydroxyestrone? |
| A: The English name of 2-hydroxyestrone is 2-hydroxyestrone. |
| Q: What are the uses of 2-hydroxyestrone? |
| A: Main uses of 2-hydroxyestrone: 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2]. |
| Q: What is the molecular formula of 2-hydroxyestrone? |
| A: Molecular formula of 2-hydroxyestrone is C18H22O3. |
| Q: What is the polar surface area (PSA) of 2-hydroxyestrone? |
| A: Polar surface area (PSA) of 2-hydroxyestrone is 57.53000. |
| Q: What is the molecular weight of 2-hydroxyestrone? |
| A: Molecular weight of 2-hydroxyestrone is 286.36500. |
| Q: What is the melting point of 2-hydroxyestrone? |
| A: Melting point of 2-hydroxyestrone is 199-201ºC. |
| Q: What are the storage conditions for 2-hydroxyestrone? |
| A: Storage conditions for 2-hydroxyestrone: 2-8°C. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |