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36505-84-7

36505-84-7 structure

36505-84-7 structure

Name: Buspirone
Chemical Name: buspirone
CAS Number: 36505-84-7
Molecular Formula: C₂₁H₃₁N₅O₂
Molecular Weight: 385.50300
Catalog: API Nervous system medication Anxiolytic
Create Date: 2018-03-24 08:00:00
Modify Date: 2026-07-10 18:37:34
Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2].

Name	buspirone
Synonyms	Birone //BP Birone (base and/or unspecified salts) Birone for system suitability CRS Bisal Refametinib Impurity 5 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspirodecane-7,9-quinone MFCD00078569 5-Chloro Birone Buspironum [INN-Latin] 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE HYDROCHLORIDE Buspironum Ansiced 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspirodecane-7,9-dione 36-7 Birone Bespar Birone free base 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspirodecane-7,9-dione - [AC80022] BIRONE HCL Buspirona [INN-Spanish] [14C]-Buspirone Bimen Birone Impurity Nd：Tmvin Buspirona Ansial 5)decane-7,9-dione,8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-8-azaspiro( 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione EINECS 253-072-2 Anxiron BUPROPIONHCL Birone Impurity D Hydrochloride 5-HT Rector,inhibit,5-hydroxytryptamine Rector,Serotonin Rector,Reactive Oxygen Species,anxiety,Birone,Inhibitor,dression,5-HT1A rector Ansiced：Axoren BIRONE 8-(4-(4-(2-pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione 8-Azaspirodecane-7,9-dione,8-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]

Description	Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Buspirone (0-400 µg/mL; 6 hours) has cytotoxic effect in Lymphocytes[1].Buspirone (0-180 µg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[1]. Cell Viability Assay[1] Cell Line: Lymphocytes Concentration: 0, 4, 20, 40, 200 and 400 µg/mL Incubation Time: 6 hours Result: Decreased cell viability in a dose-dependent manner.
In Vivo	Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors[2]. Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota[2]. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced the IS- or EC-induced gut Proteobacteria population.
References	[1]. Salimi A, et, al. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Curr Clin Pharmacol. 2018;13(2):120-127. [2]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094.

Density	1.24g/cm3
Boiling Point	613.9ºC at 760 mmHg
Melting Point	41678ºC
Molecular Formula	C₂₁H₃₁N₅O₂
Molecular Weight	385.50300
Flash Point	325.1ºC
Exact Mass	385.24800
PSA	69.64000
LogP	2.02900
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL9910000

CHEMICAL NAME :: 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-

CAS REGISTRY NUMBER :: 36505-84-7

BEILSTEIN REFERENCE NO. :: 0964904

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H31-N5-O2

MOLECULAR WEIGHT :: 385.57

WISWESSER LINE NOTATION :: T6VNV EXTJ B4- AT6N DNTJ D- BT6N CNJ&& E-& AL5XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 399 mg/kg/19D-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,409,1976

Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	CL9915000
HS Code	2933990090

Precursor 10
1075-89-4 81461-73-6 20980-22-7 80827-62-9
118286-98-9 5662-95-3 33386-20-8 118286-97-8
25032-23-9 110-52-1
DownStream 1
125481-61-0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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