(S)-Verapamil hydrochloride

Modify Date: 2024-01-05 11:30:15

(S)-Verapamil hydrochloride Structure
(S)-Verapamil hydrochloride structure
Common Name (S)-Verapamil hydrochloride
CAS Number 36622-28-3 Molecular Weight 491.06300
Density N/A Boiling Point N/A
Molecular Formula C27H39ClN2O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of (S)-Verapamil hydrochloride


(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].

 Names

Name S(−)-Verapamil hydrochloride hydrate
Synonym More Synonyms

 (S)-Verapamil hydrochloride Biological Activity

Description (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].
Related Catalog
Target

LTC4

Ca2+

In Vitro (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].
References

[1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.

[2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

 Chemical & Physical Properties

Molecular Formula C27H39ClN2O4
Molecular Weight 491.06300
Exact Mass 490.26000
PSA 63.95000
LogP 5.89508

 Safety Information

RIDADR UN 2811 6.1/PG 3

 Synonyms

s(-)-verapamil
MFCD00069355
EINECS 253-132-8
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