2,4-Difluoroaniline

Modify Date: 2026-07-01 11:07:28

2,4-Difluoroaniline structure	Common Name	2,4-Difluoroaniline
	CAS Number	367-25-9	Molecular Weight	129.107
	Density	1.3±0.1 g/cm3	Boiling Point	168.4±20.0 °C at 760 mmHg
	Molecular Formula	C₆H₅F₂N	Melting Point	−7.5 °C(lit.)
	MSDS	Chinese USA	Flash Point	62.8±0.0 °C
	Symbol	GHS06	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2,4-Difluoroaniline
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	168.4±20.0 °C at 760 mmHg
Melting Point	−7.5 °C(lit.)
Molecular Formula	C₆H₅F₂N
Molecular Weight	129.107
Flash Point	62.8±0.0 °C
Exact Mass	129.039001
PSA	26.02000
LogP	1.52
Vapour Pressure	1.6±0.3 mmHg at 25°C
Index of Refraction	1.521
InChIKey	CEPCPXLLFXPZGW-UHFFFAOYSA-N
SMILES	Nc1ccc(F)cc1F
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
Water Solubility	1-5 g/100 mL at 20.55 ºC

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2,4-Difluoroaniline MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX3680000

CHEMICAL NAME :: Aniline, 2,4-difluoro-

CAS REGISTRY NUMBER :: 367-25-9

BEILSTEIN REFERENCE NO. :: 2802556

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H5-F2-N

MOLECULAR WEIGHT :: 129.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H302-H311-H331
Precautionary Statements	P261-P280-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S28-S36/37/39-S26
RIDADR	UN 2941 6.1/PG 3
WGK Germany	1
RTECS	BX3680000
Packaging Group	III
Hazard Class	6.1
HS Code	2921420090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:36556-48-6 2-Chloro-3,4-di... CAS#:2613-34-5 3-Chloro-2,4-di... CAS#:1481-68-1 1-Chloro-2,4-di... CAS#:88-73-3 2-Nitrochlorobenzene
CAS#:446-35-5 2,4-Difluoronit... CAS#:3296-04-6 1-Azido-2-fluor... CAS#:89-69-0 1,2,4-Trichloro... CAS#:3847-58-3 2-Chloro-1,3-di...
CAS#:108-70-3 1,3,5-Trichloro... CAS#:371-40-4 4-Fluoroaniline
DownStream 10
CAS#:108138-27-8 1-(2,4-difluoro... CAS#:456-49-5 3-Fluoroanisole CAS#:367-34-0 2,4,5-Trifluoro... CAS#:3862-73-5 2,3,4-Trifluoro...
CAS#:372-18-9 1,3-Difluorobenzene CAS#:367-27-1 2,4-Difluorophenol CAS#:37847-52-2 2,4-Difluorobiphenyl CAS#:53591-79-0 1-(2',4'-difluo...
CAS#:367-23-7 1,2,4-Trifluoro... CAS#:32085-88-4 3,5-Difluoroben...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2921420090
Summary	HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses.

Int. Arch. Occup. Environ. Health 54(3) , 223-32, (1984)

Two possible methods for monitoring exposure to 2,4-difluoroaniline and 4-fluoroaniline have been investigated: measurement of methaemoglobin content in blood and measurement of urinary metabolites. E...

Subacute toxicity assessment of water disinfection byproducts on zebrafish.

Pathol. Oncol. Res. 18(3) , 579-84, (2012)

Disinfection of raw water is essential to the production of drinking water. However, by-products of disinfection may exert toxic effects. The potential toxic effects of two of these compounds, 4-ethyl...

High resolution NMR study of T1 magnetic relaxation dispersion. III. Influence of spin 1/2 hetero-nuclei on spin relaxation and polarization transfer among strongly coupled protons.

J. Chem. Phys. 137(9) , 094503, (2012)

Effects of spin-spin interactions on the nuclear magnetic relaxation dispersion (NMRD) of protons were studied in a situation where spin ½ hetero-nuclei are present in the molecule. As in earlier work...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 212, Current Page 1 of 22

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2,4-difluorophenylamine

2,4-DIFLOUROANILINE

Difluoroaniline

4-Difluoroaniline

2,4-Difluoranilin

2,4-difluoro-anilin

2,4-difluorobenzenamine

2,4-difluorobenzeneamine

Aniline,2,4-difluoro

EINECS 206-687-5

2,4-Difluoroaniline

4-fluoro-2-fluoroaniline

MFCD00007648

2,4-Difluoro-aniline

2,4-DIFLUROANILINE

2,4,6-TRIFLUOROPHENYL ISOCYANATE

2,4-fluoroaniline

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does 2,4-Difluoroaniline have?

A: English synonyms of 2,4-Difluoroaniline: 2,4-difluorophenylamine, 2,4-DIFLOUROANILINE, Difluoroaniline, 4-Difluoroaniline, 2,4-Difluoranilin, 2,4-difluoro-anilin, 2,4-difluorobenzenamine, 2,4-difluorobenzeneamine, Aniline,2,4-difluoro, EINECS 206-687-5, 2,4-Difluoroaniline, 4-fluoro-2-fluoroaniline, MFCD00007648, 2,4-Difluoro-aniline, 2,4-DIFLUROANILINE, 2,4,6-TRIFLUOROPHENYL ISOCYANATE, 2,4-fluoroaniline.

Q: What is the molecular weight of 2,4-Difluoroaniline?

A: Molecular weight of 2,4-Difluoroaniline is 129.107.

Q: What is the polar surface area (PSA) of 2,4-Difluoroaniline?

A: Polar surface area (PSA) of 2,4-Difluoroaniline is 26.02000.

Q: What is the InChIKey of 2,4-Difluoroaniline?

A: InChIKey of 2,4-Difluoroaniline is CEPCPXLLFXPZGW-UHFFFAOYSA-N.

Q: What are the upstream materials of 2,4-Difluoroaniline?

A: Related upstream materials(CAS) of 2,4-Difluoroaniline: 36556-48-6;2613-34-5;1481-68-1;88-73-3;446-35-5;3296-04-6;89-69-0;3847-58-3;108-70-3;371-40-4.

Q: What is the SMILES notation of 2,4-Difluoroaniline?

A: SMILES notation of 2,4-Difluoroaniline is Nc1ccc(F)cc1F.

Q: How is the water solubility of 2,4-Difluoroaniline?

A: Water solubility of 2,4-Difluoroaniline: 1-5 g/100 mL at 20.55 ºC.

Q: What is the molecular formula of 2,4-Difluoroaniline?

A: Molecular formula of 2,4-Difluoroaniline is C6H5F2N.

Q: What is the LogP of 2,4-Difluoroaniline?

A: LogP of 2,4-Difluoroaniline is 1.52.

Q: What is the CAS number of 2,4-Difluoroaniline?

A: CAS number of 2,4-Difluoroaniline is 367-25-9.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,4-Difluoroaniline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,4-Difluoroaniline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,4-Difluoroaniline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2,4-Difluoroaniline
Price: ￥Inquiry/1kg ￥Inquiry/25kg ￥Inquiry/200kg
Purity: 99.0%
Delivery: 3 Day
Contact: Wang Jie
Email: 3096638339@qq.com

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2,4-Difluoroaniline

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Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

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2,4-DifluoroanilineBioassay

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2,4-Difluoroaniline | FAQ

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.