Zinterol
Modify Date: 2024-01-08 09:23:17
Zinterol structure
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Common Name | Zinterol | ||
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| CAS Number | 37000-20-7 | Molecular Weight | 378.48600 | |
| Density | 1.282g/cm3 | Boiling Point | 574.3ºC at 760mmHg | |
| Molecular Formula | C19H26N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 301.1ºC | |
Use of ZinterolZinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. |
| Name | N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. |
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| Related Catalog | |
| Target |
β2-adrenoceptor[1] |
| In Vivo | Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3]. Animal Model: In New Zealand White HF rabbits of either sex[3] Dosage: 1.0 or 2.5 μg/kg Administration: Intravenous bolus administration; over 5 seconds Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |
| References |
| Density | 1.282g/cm3 |
|---|---|
| Boiling Point | 574.3ºC at 760mmHg |
| Molecular Formula | C19H26N2O4S |
| Molecular Weight | 378.48600 |
| Flash Point | 301.1ºC |
| Exact Mass | 378.16100 |
| PSA | 107.04000 |
| LogP | 3.95270 |
| Index of Refraction | 1.615 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
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| HS Code | 2935009090 |
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
| ZINTEROL |
| MJ-9184-1 |
| Zinterolum |
| Allopregnanolone |