ccpa

Modify Date: 2025-08-22 16:41:47

ccpa Structure
ccpa structure
 Common Name ccpa
CAS Number 37739-05-2 Molecular Weight 369.80
Density 1.87g/cm3 Boiling Point 617.3ºC at 760mmHg
Molecular Formula C15H20ClN5O4 Melting Point N/A
MSDS Chinese USA Flash Point 327.1ºC

 Use of ccpa


CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-Chloro-N6-cyclopentyl Adenosine
Synonym More Synonyms

 ccpa Biological Activity

Description CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.87g/cm3
Boiling Point 617.3ºC at 760mmHg
Molecular Formula C15H20ClN5O4
Molecular Weight 369.80
Flash Point 327.1ºC
Exact Mass 369.12000
PSA 125.55000
LogP 0.51870
Index of Refraction 1.824
Storage condition 2-8°C
Water Solubility H2O: 1.7 mg/mL, insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7357555
CHEMICAL NAME :
Adenosine, 2-chloro-N-cyclopentyl-
CAS REGISTRY NUMBER :
37739-05-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H20-Cl-N5-O4
MOLECULAR WEIGHT :
369.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1305,1994

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AU7357555

 Articles50

More Articles
Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse.

Eur. J. Neurosci. 42 , 1775-87, (2015)

Adenosine receptors (ARs) are present in the motor terminals at the mouse neuromuscular junction. ARs and the presynaptic muscarinic acetylcholine receptors (mAChRs) share the functional control of th...

Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.

Clin. Microbiol. Infect. 20(11) , O960-8, (2014)

Chronic cavitary pulmonary aspergillosis (CCPA) is an uncommon but serious pulmonary disease of humans, with an annual mortality rate of 10-30%. It is caused by the fungus Aspergillus fumigatus. Patie...

Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281.

Cell. Signal. 27(5) , 1008-18, (2015)

Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemothera...

 Synonyms

2-Chloro-N-cyclopentyladenosine
2-Chloro-N6-cyclopentyladenosine
2-Chloro-N6-cyclopentyladenosine,2-Chloro-N-cyclopentyladenosine
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