Zaprinast

Modify Date: 2024-01-02 19:11:34

Zaprinast structure	Common Name	Zaprinast
	CAS Number	37762-06-4	Molecular Weight	271.275
	Density	1.484g/cm3	Boiling Point	406.3±47.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₃N₅O₂	Melting Point	237-238ºC dec.
	MSDS	Chinese USA	Flash Point	199.5±29.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Zaprinast

Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].

Name	zaprinast
Synonym	More Synonyms

Description	Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Neurological Disease
Target	PDE[1], GPR35[2]
References	[1]. Choi SH , et al. Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. J Neurosci Res. 2002 Feb 1;67(3):411-21. [2]. Taniguchi Y, et al. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 2006 Sep 18;580(21):5003-8. Epub 2006 Aug 17. [3]. Keswani AN , et al The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. J Cardiovasc Pharmacol Ther. 2009 Jun;14(2):116-24.

Density	1.484g/cm3
Boiling Point	406.3±47.0 °C at 760 mmHg
Melting Point	237-238ºC dec.
Molecular Formula	C₁₃H₁₃N₅O₂
Molecular Weight	271.275
Flash Point	199.5±29.3 °C
Exact Mass	271.106934
PSA	96.55000
LogP	0.17
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.719
Storage condition	2-8℃
Water Solubility	Soluble to 100 mM in DMSO

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XZ6157358

Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells.

PLoS ONE 9(12) , e114019, (2014)

Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molec...

Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.

J. Biol. Chem. 288(50) , 36129-40, (2013)

Transport of pyruvate into mitochondria by the mitochondrial pyruvate carrier is crucial for complete oxidation of glucose and for biosynthesis of amino acids and lipids. Zaprinast is a well known pho...

GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.

PLoS ONE 8 , e82180, (2013)

Limited information is available on the brain expression and role of GPR35, a Gi/o coupled receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected GPR35 transcript using...

1H-1,2,3-triazolo[4,5-d]pyrimidin-7-ol, 5-(2-propoxyphenyl)-

2-(2-PROPYLOXYPHENYL)-8-AZAPURIN-6-ONE

5-(2-Propoxyphenyl)-1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one

2-o-propoxyphenyl-8-azapurin-6-one

EINECS 253-655-1

Potassium phosphate monobasic

Zaprinast

3,6-dihydro-5-(2-propoxyphenyl)

Phenylaza purinon

2-(2-Propoxyphenyl)-8-azahypoxanthine

MFCD00214073

5-(2-Propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one

7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one, 3,4-dihydro-5-(2-propoxyphenyl)-

B 22,948

8-Aza-2-(2-propoxyphenyl)-6-purinone

5-(2-propoxyphenyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one

7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 1,4-dihydro-5-(2-propoxyphenyl)-

5-(2-Propoxyphenyl)-3,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one

1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one

1,4-Dihydro-5-(2-propoxyphenyl)-1,2,3-triazolo[4,5-d]pyrimidin-7-one

7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 2,3-dihydro-5-(2-propoxyphenyl)-

DC Chemicals Limited
China
Product Name: Zaprinast
Price: $200.0/100mg $400.0/250mg $600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Zaprinast

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