Oxylone acetate

Modify Date: 2025-08-23 18:43:25

Oxylone acetate Structure
Oxylone acetate structure
 Common Name Oxylone acetate
CAS Number 3801-06-7 Molecular Weight 418.498
Density 1.2±0.1 g/cm3 Boiling Point 532.1±50.0 °C at 760 mmHg
Molecular Formula C24H31FO5 Melting Point 230-232°
MSDS N/A Flash Point 275.6±30.1 °C

 Use of Oxylone acetate


Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[1][2][3].

 Names

Name fluorometholone acetate
Synonym More Synonyms

 Oxylone acetate Biological Activity

Description Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[1][2][3].
Related Catalog
Target

IC50: 2.18 μM (human carbonic anhydrase (hCA)-I) and 17.5 μM (hCA-II)[2] Ki: 1.044 μM (hCA-I) and 9.98 μM (hCA-II)[2]

In Vitro For Fluorometholone acetate, a Ki value from Lineweaver-Burk plots is obtained as 1.044 μM (noncompetitive) for hCA-I and 9.98 μM (non-competitive) for hCA-II[2].
In Vivo Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension[1].
References

[1]. A Kupferman, et al. Fluorometholone acetate. A new ophthalmic derivative of fluorometholone. Arch Ophthalmol. 1982 Apr;100(4):640-1.

[2]. Zuhal Alım, et al. Some Anti-Inflammatory Agents Inhibit Esterase Activities of Human Carbonic Anhydrase Isoforms I and II: An In Vitro Study. Chem Biol Drug Des. 2015 Oct;86(4):857-63.

[3]. H M Leibowitz, et al. Fluoro metholone acetate: clinical evaluation in the treatment of external ocular inflammation. Ann Ophthalmol. 1984 Dec;16(12):1110-5.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 532.1±50.0 °C at 760 mmHg
Melting Point 230-232°
Molecular Formula C24H31FO5
Molecular Weight 418.498
Flash Point 275.6±30.1 °C
Exact Mass 418.215546
PSA 80.67000
LogP 2.57
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.556

 Safety Information

RIDADR NONH for all modes of transport
HS Code 2942000000

 Customs

HS Code 2942000000

 Synonyms

Oxylone acetate
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate
FLUOROMETHOLONE ACETATE
acétate de (6S,8S,9R,10S,11S,13S,14S,17R)-17-acétyl-9-fluoro-11-hydroxy-6,10,13-triméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yle
[(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
(6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluor-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylacetat
Pregna-1,4-diene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-6-methyl-, (6α,11β)-
(6α,11β)-9-Fluoro-11-hydroxy-6-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate
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