[(pF)Phe4]Nociceptin(1-13)NH2

Modify Date: 2024-02-05 13:06:01

[(pF)Phe4]Nociceptin(1-13)NH2 structure	Common Name	[(pF)Phe4]Nociceptin(1-13)NH2
	CAS Number	380620-88-2	Molecular Weight	1471.54000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₁H₉₉FN₂₂O₁₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [(pF)Phe4]Nociceptin(1-13)NH2

[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP (OP4) agonists, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].

Name	[(pF)Phe4]Nociceptin(1-13)NH2
Synonym	More Synonyms

Description	[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP (OP4) agonists, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vivo	In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2[2].
References	[1]. Rizzi A, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):450-456. [2]. Bigoni R, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):442-449. [3]. Guerrini R, et al. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44(23):3956-3964.