[Nphe1]Nociceptin(1-13)NH2 TFA

Modify Date: 2025-08-31 22:44:36

[Nphe1]Nociceptin(1-13)NH2 TFA structure	Common Name	[Nphe1]Nociceptin(1-13)NH2 TFA
	CAS Number	267234-08-2	Molecular Weight	1381.59000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₁H₁₀₀N₂₂O₁₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [Nphe1]Nociceptin(1-13)NH2 TFA

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].

Name	[Nphe1]Nociceptin(1-13)NH2
Synonym	More Synonyms

Description	[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vitro	[Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).
References	[1]. Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor [2]. G Calo', et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol. 2000 Mar;129(6):1183-93.

Molecular Formula	C₆₁H₁₀₀N₂₂O₁₅
Molecular Weight	1381.59000
Exact Mass	1380.77000
PSA	620.62000
LogP	0.97790
InChIKey	NMBZIPCESQREMT-UVDGFCMYSA-N
SMILES	CC(NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNCc1ccccc1)C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCCN)C(N)=O

WGK Germany	3

BzlGlyGGFTGARKSARK-NH2

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: [Nphe1]Nociceptin(1-13)NH2 TFA
Price: Check
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: [Nphe1]Nociceptin(1-13)NH2
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [NPHE1]NOCICEPTIN(1-13)NH2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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