Carbidopa monohydrate structure
|
Common Name | Carbidopa monohydrate | ||
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CAS Number | 38821-49-7 | Molecular Weight | 244.244 | |
Density | 1.42 g/cm3 | Boiling Point | 528.7ºC at 760 mmHg | |
Molecular Formula | C10H16N2O5 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 273.5ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Carbidopa monohydrateCarbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2]. |
Name | carbidopa |
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Synonym | More Synonyms |
Description | Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2]. |
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Related Catalog | |
In Vitro | Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191[1]. Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC50=29 μM)[3]. |
In Vivo | Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts[1]. |
References |
Density | 1.42 g/cm3 |
---|---|
Boiling Point | 528.7ºC at 760 mmHg |
Molecular Formula | C10H16N2O5 |
Molecular Weight | 244.244 |
Flash Point | 273.5ºC |
Exact Mass | 244.105927 |
PSA | 125.04000 |
LogP | 0.97380 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H319 |
Precautionary Statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2932999099 |
HS Code | 2928000090 |
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Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-, hydrate (1:1) |
CARBIDOPA 1-HYDRATE,PHARMA |
Carbidopa |
(S)-Carbidopa |
1-a-(3,4-Dihydroxybenzyl)-a-hydrazinopropionic Acid |
L-a-Methyldopahydrazine |
(aS)-a-Hydrazino-3,4-dihydroxy-a-methylbenzenepropanoic Acid |
CARBIDOPA MONOHYDRATE |
(S)-(-)-CARBIDOPA MONOHYDRATE |
a-Methyldopahydrazine |
Lodosin |
carbidopa [INN_en] |
CARBIDOPA HYDRATE |
CARBIDOPA(GMP CERTIFICATE) |
(S)-(-)-Carbidopa |
HMD |
CARBIDOPA,USP |
(2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid hydrate (1:1) |
(2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid |
S-(−)-Carbidopa |
(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate |
Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)- |
CARBIDOPA 1-HYDRATE |
benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (αS)- |
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (1:1) |
MFCD00889211 |
benzenepropanoic acid, a-hydrazinyl-3,4-dihydroxy-a-methyl-, (aS)- |
Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (S)- |
lodosyn |
S-(-)-Carbidopa |
(-)-L-a-Hydrazino-3,4-dihydroxy-a-methylhydrocinnamic Acid |
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid |
Hydrazino-a-methyldopa |