Picroside II

Modify Date: 2024-01-02 11:46:55

Picroside II Structure
Picroside II structure
Common Name Picroside II
CAS Number 39012-20-9 Molecular Weight 512.461
Density 1.7±0.1 g/cm3 Boiling Point 780.8±60.0 °C at 760 mmHg
Molecular Formula C23H28O13 Melting Point N/A
MSDS USA Flash Point 267.9±26.4 °C

 Use of Picroside II


Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways[1]. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury[2].

 Names

Name Picroside II
Synonym More Synonyms

 Picroside II Biological Activity

Description Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways[1]. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury[2].
Related Catalog
References

[1]. Huang Y, et al. Picroside II protects against sepsis via suppressing inflammation in mice. Am J Transl Res. 2016 Dec 15;8(12):5519-5531. eCollection 2016.

[2]. Zhai L, et al. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS One. 2017 Apr 7;12(4):e0174414.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 780.8±60.0 °C at 760 mmHg
Molecular Formula C23H28O13
Molecular Weight 512.461
Flash Point 267.9±26.4 °C
Exact Mass 512.153015
PSA 197.13000
LogP -2.50
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.681
Storage condition 2-8°C
Water Solubility ethanol: soluble1mg/mL, clear, colorless

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport

 Synonyms

AMPHICOSIDE
Amphicoside II
PicrosideII
Vanilloyl catalpol
Picroside-2
6'-VANILLOYL CATALPOL
2-(Hexopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxy-3-methoxybenzoate
PICROSID II
Benzoic acid, 4-hydroxy-3-methoxy-, 2-(hexopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester
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