16,16-Dimethyl prostaglandin E2

Modify Date: 2024-02-03 18:28:02

16,16-Dimethyl prostaglandin E2 structure	Common Name	16,16-Dimethyl prostaglandin E2
	CAS Number	39746-25-3	Molecular Weight	380.518
	Density	1.1±0.1 g/cm3	Boiling Point	541.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₆O₅	Melting Point	-85.6ºC
	MSDS	Chinese USA	Flash Point	295.2±26.6 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of 16,16-Dimethyl prostaglandin E2

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].

Name	16,16-Dimethylprostaglandin E2
Synonym	More Synonyms

Description	16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	EP2 EP4
In Vivo	16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 µg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2IMF-KO mice and restores epithelial proliferation and structure[2]. Animal Model: Tpl2IMF-KO mice[2] Dosage: 10 µg/kg Administration: IP; every 12 hours; for 8 days Result: Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure.
References	[1]. Hagedorn EJ, et al. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. xp Cell Res. 2014 Dec 10;329(2):220-6. [2]. Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67.

Density	1.1±0.1 g/cm3
Boiling Point	541.3±50.0 °C at 760 mmHg
Melting Point	-85.6ºC
Molecular Formula	C₂₂H₃₆O₅
Molecular Weight	380.518
Flash Point	295.2±26.6 °C
Exact Mass	380.256287
PSA	94.83000
LogP	2.57
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.551

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK7894000

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11-alpha,13E,15R)-

CAS REGISTRY NUMBER :: 39746-25-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H36-O5

MOLECULAR WEIGHT :: 380.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 ug/kg

SEX/DURATION :: female 34 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 6,349,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 64 ug/kg

SEX/DURATION :: female 6 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,167,1977

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319-H336
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F,Xn,Xi
Risk Phrases	11-20/21/22-36/37/38-67-66-36
Safety Phrases	16-26-36
RIDADR	UN 1231 3/PG 2

methyl (Z)-7-[(...

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16,16-Dimethyl ...

CAS#:39746-25-3

Literature: Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282

N/A

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16,16-Dimethyl ...

CAS#:39746-25-3

Literature: Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282

(R,E)-((1-iodo-...

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16,16-Dimethyl ...

CAS#:39746-25-3

Literature: Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282

methyl (Z)-7-((...

CAS#:61263-34-1

16,16-Dimethyl ...

CAS#:39746-25-3

Literature: Rodriguez, Ana; Nomen, Miguel; Spur, Bernd W.; Godfroid, Jean-Jacques Archiv der Pharmazie, 1998 , vol. 331, # 9 p. 279 - 282

Precursor 2
CAS#:42782-96-7 methyl (Z)-7-[(... CAS#:61263-34-1 methyl (Z)-7-((...
DownStream 1
CAS#:41691-92-3 16,16-dimethyl ...

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(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid

Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11α,13E,15R)-

16,16-Dimethyl Prostaglandin E2,(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oicacid

Shanghai Nianxing Industrial Co., Ltd
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Product Name: 16,16-DIMETHYLPROSTAGLANDINE2
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 16,16-DIMETHYL PROSTAGLANDIN E2
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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