DMeOB

Modify Date: 2024-01-10 08:33:29

DMeOB Structure
DMeOB structure
Common Name DMeOB
CAS Number 40252-74-2 Molecular Weight 268.31
Density 1.05g/cm3 Boiling Point 438.2ºC at 760mmHg
Molecular Formula C16H16N2O2 Melting Point N/A
MSDS Chinese USA Flash Point 176.1ºC
Symbol GHS05 GHS09
GHS05, GHS09
Signal Word Danger

 Use of DMeOB


DMeOB is an agonist of mGluR5 receptor with an IC50 of 3 μM. DMeOB has a negative modulatory effect[1].

 Names

Name (E)-1-(3-methoxyphenyl)-N-[(E)-(3-methoxyphenyl)methylideneamino]methanimine
Synonym More Synonyms

 DMeOB Biological Activity

Description DMeOB is an agonist of mGluR5 receptor with an IC50 of 3 μM. DMeOB has a negative modulatory effect[1].
Related Catalog
References

[1]. O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003 Sep;64(3):731-40.  

 Chemical & Physical Properties

Density 1.05g/cm3
Boiling Point 438.2ºC at 760mmHg
Molecular Formula C16H16N2O2
Molecular Weight 268.31
Flash Point 176.1ºC
Exact Mass 268.12100
PSA 43.18000
LogP 3.15680
Index of Refraction 1.54
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS09
GHS05, GHS09
Signal Word Danger
Hazard Statements H318-H400
Precautionary Statements P273-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;N: Dangerous for the environment;
Risk Phrases 41-50/53
Safety Phrases 26-36/37/39-60-61
RIDADR UN 3077 9/PG 3

 Synthetic Route

~80%

DMeOB Structure

DMeOB

CAS#:40252-74-2

Literature: O'Brien, Julie A.; Lemaire, Wei; Chen, Tsing-Bau; Chang, Raymond S. L.; Jacobson, Marlene A.; Ha, Sookhee N.; Lindsley, Craig W.; Schaffhauser, Herve J.; Sur, Cyrille; Pettibone, Douglas J.; Conn, P. Jeffrey; Williams Jr., David L. Molecular Pharmacology, 2003 , vol. 64, # 3 p. 731 - 740

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DMeOB Structure

DMeOB

CAS#:40252-74-2

Literature: Pietra; Trinchera Gazzetta Chimica Italiana, 1956 , vol. 86, p. 1045,1050

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DMeOB Structure

DMeOB

CAS#:40252-74-2

Detail
Literature: Tomioka, Hideo; Tabayashi, Kazuo; Ozaki, Yasuji; Izawa, Yasuji Tetrahedron, 1985 , vol. 41, # 8 p. 1435 - 1440

 Articles1

More Articles
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

Mol. Pharmacol. 64 , 731-740, (2003)

We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of eff...

 Synonyms

3,3'-dimethoxybenzalazine
DMeOB
m-anisaldehyde azine
3,3'-dimethoxybenzaldazine
3-Methoxybenzaldehyde [(3-methoxyphenyl)methylene]hydrazone
3-methoxybenzaldehyde azine
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