ODQ

Modify Date: 2024-01-23 20:00:22

ODQ Structure
ODQ structure
 Common Name ODQ
CAS Number 41443-28-1 Molecular Weight 187.155
Density 1.6±0.1 g/cm3 Boiling Point 321.3±25.0 °C at 760 mmHg
Molecular Formula C9H5N3O2 Melting Point 160-170 °C
MSDS Chinese USA Flash Point 148.1±23.2 °C

 Use of ODQ


ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1].

 Names

Name [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
Synonym More Synonyms

 ODQ Biological Activity

Description ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1].
Related Catalog
In Vitro At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[1].
In Vivo ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[2]. Animal Model: Anesthetized, male Wistar rats[2] Dosage: 2 mg/kg Administration: I.p. Result: Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.
References

[1]. Ronald Fiscus, et al. ODQ, an inhibitor of soluble guanylyl cyclase (nitric oxide-activated enzyme), enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. Cancer Res May 1 2007 (67) (9 Supplement) LB-43.

[2]. Zacharowski K, et al. The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med. 2001;29(8):1599-1608.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 321.3±25.0 °C at 760 mmHg
Melting Point 160-170 °C
Molecular Formula C9H5N3O2
Molecular Weight 187.155
Flash Point 148.1±23.2 °C
Exact Mass 187.038177
PSA 60.40000
LogP 0.28
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.781
Storage condition 2-8°C
Water Solubility ethanol: 1.2 mg/mL

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles59

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 Synonyms

[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Lopac-O-3636
T B566 BNVON HNJ
1H-[1,2,4]oxadiazolol[4,3,-a]quinoxalin-1-one
Tocris-0880
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
MFCD00792620
1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
ODQ
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
1-H-[1,2,4]Oxadiazolo-[4,3,2]quinoxalin-1-ine
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Chemsrc provides ODQ(CAS#:41443-28-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ODQ are included as well.>> amp version: ODQ

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