DPO-1
DPO-1 structure
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Common Name | DPO-1 | ||
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| CAS Number | 43077-30-1 | Molecular Weight | 340.43900 | |
| Density | 1.054g/cm3 | Boiling Point | 434.966ºC at 760 mmHg | |
| Molecular Formula | C22H29OP | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 216.86ºC | |
Use of DPO-1DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia[1][2]. |
| Name | [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene |
|---|---|
| Synonym | More Synonyms |
| Description | DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.054g/cm3 |
|---|---|
| Boiling Point | 434.966ºC at 760 mmHg |
| Molecular Formula | C22H29OP |
| Molecular Weight | 340.43900 |
| Flash Point | 216.86ºC |
| Exact Mass | 340.19600 |
| PSA | 26.88000 |
| LogP | 5.46130 |
| Index of Refraction | 1.547 |
| InChIKey | BPCNGVCAHAIZEE-COPCDDAFSA-N |
| SMILES | CC1CCC(C(C)C)C(P(=O)(c2ccccc2)c2ccccc2)C1 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2902909090 |
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~56%
DPO-1 CAS#:43077-30-1 |
| Literature: Yamashita, Mitsuji; Soeda, Yukio; Suzuki, Nobuyoshi; Yamada, Manabu; Tsunekawa, Kenji; et al. Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 6 p. 1871 - 1872 Title/Abstract Full Text Show Details Yamashita, Mitsuji; Suzuki, Nobuyoshi; Yamada, Manabu; Soeda, Yukio; Yamashita, Hiroaki; et al. Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 1 p. 219 - 222 |
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~%
DPO-1 CAS#:43077-30-1 |
| Literature: Beaumont; Kiely; Rooney Journal of Fluorine Chemistry, 2001 , vol. 108, # 1 p. 47 - 50 |
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~%
DPO-1 CAS#:43077-30-1 |
| Literature: Yamashita, Mitsuji; Suzuki, Nobuyoshi; Yamada, Manabu; Soeda, Yukio; Yamashita, Hiroaki; et al. Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 1 p. 219 - 222 |
| HS Code | 2902909090 |
|---|---|
| Summary | 2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0% |
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Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.
Oncogene 34 , 4591-600, (2015) Relapse after clinical remission remains a leading cause of cancer-associated death. Although the mechanisms of tumor relapse are complex, the ability of cancer cells to survive physiological stress i... |
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HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction.
Cardiovasc. Res. 109 , 115-30, (2015) Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is i... |
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Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.
PLoS ONE 8 , e64629, (2013) Diphenyl phosphine oxide-1 (DPO-1) is a potent Kv1.5 channel inhibitor that has therapeutic potential for the treatment of atrial fibrillation. Many other Kv1.5 channel blockers also potently inhibit ... |
| DPO-1 |
| HMS3269O11 |
| neomenthyldiphenylphosphine oxide |
| Neomenthyldiphenylphosphin-oxid |
| HMS3261N07 |