DPO-1
DPO-1 structure
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Common Name | DPO-1 | ||
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| CAS Number | 43077-30-1 | Molecular Weight | 340.43900 | |
| Density | 1.054g/cm3 | Boiling Point | 434.966ºC at 760 mmHg | |
| Molecular Formula | C22H29OP | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 216.86ºC | |
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Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.
Oncogene 34 , 4591-600, (2015) Relapse after clinical remission remains a leading cause of cancer-associated death. Although the mechanisms of tumor relapse are complex, the ability of cancer cells to survive physiological stress is a prerequisite for recurrence. Ewing sarcoma (ES) and neu... |
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HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction.
Cardiovasc. Res. 109 , 115-30, (2015) Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is involved in the maintenance of lung homeostasis. New work id... |
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Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.
PLoS ONE 8 , e64629, (2013) Diphenyl phosphine oxide-1 (DPO-1) is a potent Kv1.5 channel inhibitor that has therapeutic potential for the treatment of atrial fibrillation. Many other Kv1.5 channel blockers also potently inhibit the Kv1.3 channel, but whether DPO-1 blocks Kv1.3 channels ... |
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Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.
PLoS ONE 9(5) , e96643, (2014) The electrogenic machinery of an excitable cell can adapt in response to changes in input, genetic deficit or in pathological conditions, however the underlying molecular mechanisms are not understood. In cases of genetic deletion it is commonly observed that... |