L-Menthol

Modify Date: 2024-01-02 11:44:20

L-Menthol Structure
L-Menthol structure
 Common Name L-Menthol
CAS Number 2216-51-5 Molecular Weight 156.265
Density 0.9±0.1 g/cm3 Boiling Point 215.4±8.0 °C at 760 mmHg
Molecular Formula C10H20O Melting Point 41-43ºC
MSDS Chinese USA Flash Point 93.3±0.0 °C
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Use of L-Menthol


(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

 Names

Name (-)-menthol
Synonym More Synonyms

 L-Menthol Biological Activity

Description (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].
Related Catalog
Target

TRPM8[1]
In Vitro (-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1]. (-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1]. Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1].
References

[1]. Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44(2):125-30.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 215.4±8.0 °C at 760 mmHg
Melting Point 41-43ºC
Molecular Formula C10H20O
Molecular Weight 156.265
Flash Point 93.3±0.0 °C
Exact Mass 156.151413
PSA 20.23000
LogP 3.20
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.457
Water Solubility insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OT0700000
CHEMICAL NAME :
l-Menthol
CAS REGISTRY NUMBER :
2216-51-5
LAST UPDATED :
199701
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C10-H20-O
MOLECULAR WEIGHT :
156.30
WISWESSER LINE NOTATION :
L6TJ AY1&1 DQ D1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
34 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
10 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6896 No. of Facilities: 499 (estimated) No. of Industries: 5 No. of Occupations: 27 No. of Employees: 43996 (estimated) No. of Female Employees: 34625 (estimated)

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38;R41
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS OT0700000
HS Code 29061100

 Synthetic Route

 Customs

HS Code 2906199090
Summary 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles42

More Articles
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...
Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...
Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.

PLoS ONE 10 , e0137070, (2015)

Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular...

 Synonyms

(-)-(1R,3R,4S)-Menthol
(−)-menthol
(-)-trans-p-Methan-cis-3-ol
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
L-Menthol
(-)-(1R,2S,5R)-Menthol
(1R)-(-)-Menthol
Cyclohexanol,5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
DL-Menthol
(-)-p-Menthan-3-ol
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (5-Methyl-2-(1-methylethyl)cyclohexanol
MFCD00062979
UNII:YS08XHA860
Menthol, l-
(−)-Menthol,(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol,5-Methyl-2-(1-methylethyl)cyclohexanol
Menthol
Minclea
(1R,2S,5R)-(−)-Menthol
levo-menthol
uspmenthol
Levomenthol
(-)-MENTHYL ALCOHOL
(R)-(-)-Menthol
(1R,2S,5R)-5-methyl-2-propan-2-yl-cyclohexan-1-ol
[1R-(1a,2b,5a)]-5-Methyl-2-(1-methylethyl)cyclohexanol
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
(-)-Menthol
(−)-Menthol,(1R,2S,5R)-(−)-Menthol,(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
L(-)-Menthol
L-MentholuM
EINECS 218-690-9
(1R,2S,5R)-(-)-Menthol
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: L-Menthol
  • Price: ￥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

Get all suppliers and price by the below link:

L-Menthol suppliers

Price: ￥96.8/100g

Reference only. check more L-Menthol price

Related Compounds: More...
L-MENTHOL
4835-96-5
L-Menthol
1490-04-6
l-menthol
20752-33-4
l-Menthol acetate
16409-45-3
l-Menthol acetate
89-48-5
l-Menthol acetate
2623-23-6
L-menthol tosylate
2230-82-2
L-menthol mesylate
61548-81-0
l-Menthol propionate
4951-48-8
Chemsrc provides L-Menthol(CAS#:2216-51-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of L-Menthol are included as well.>> amp version: L-Menthol

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved