Toddaculine

Modify Date: 2025-08-21 19:33:20

Toddaculine Structure
Toddaculine structure
 Common Name Toddaculine
CAS Number 4335-12-0 Molecular Weight 274.31200
Density 1.138g/cm3 Boiling Point 432.8ºC at 760 mmHg
Molecular Formula C16H18O4 Melting Point N/A
MSDS N/A Flash Point 192.2ºC

 Use of Toddaculine


Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

 Names

Name 5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one
Synonym More Synonyms

 Toddaculine Biological Activity

Description Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
Related Catalog
In Vitro Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].
References

[1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46.

[2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158.

[3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.

 Chemical & Physical Properties

Density 1.138g/cm3
Boiling Point 432.8ºC at 760 mmHg
Molecular Formula C16H18O4
Molecular Weight 274.31200
Flash Point 192.2ºC
Exact Mass 274.12100
PSA 48.67000
LogP 3.31890
Index of Refraction 1.547
Storage condition 2-8℃

 Synthetic Route

 Synonyms

Toddaculin
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Toddaculine suppliers

Toddaculine price

Related Compounds: More...
1-(2,3-Dichlorophenyl)-4-(2,3,5,6-tetramethylbenzenesulfonyl)piperazine
1903611-23-3
(1R,3S)-3-(Trifluoromethoxy)cyclohexane-1-carboxylic acid
2375248-46-5
1-(4-Bromo-3-methoxybenzenesulfonyl)-4-(2,6-dimethylphenyl)piperazine
1808707-46-1
1-(5-Bromo-2-methoxy-4-methylbenzenesulfonyl)-4-(2,6-dimethylphenyl)piperazine
1903443-94-6
1-((4-Chloronaphthalen-1-yl)sulfonyl)-4-(2,6-dimethylphenyl)piperazine
1903689-64-4
1-(5-Chloro-2-ethoxybenzenesulfonyl)-4-(2,6-dimethylphenyl)piperazine
1903391-02-5
6-methyl-N-(1-methyl-3-phenylpropyl)-4-oxo-4,5-dihydro[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide
1775528-61-4
1-(2-bromo-4,5-dichlorobenzenesulfonyl)-3,5-dimethyl-1H-pyrazole
1903945-03-8
4-[(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl]piperazine-1-carbaldehyde
1807982-45-1
1-(4-Chloro-3-methylbenzenesulfonyl)-4-(2,6-dimethylphenyl)piperazine
1981935-04-9
Chemsrc provides Toddaculine(CAS#:4335-12-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Toddaculine are included as well.>> amp version: Toddaculine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved