Toddaculine

Modify Date: 2026-07-10 14:11:41

Toddaculine structure	Common Name	Toddaculine
	CAS Number	4335-12-0	Molecular Weight	274.31200
	Density	1.138g/cm3	Boiling Point	432.8ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₈O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	192.2ºC

Use of Toddaculine

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

Name	5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one
Synonym	More Synonyms

Description	Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
In Vitro	Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].
References	[1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. [2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. [3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.

Density	1.138g/cm3
Boiling Point	432.8ºC at 760 mmHg
Molecular Formula	C₁₆H₁₈O₄
Molecular Weight	274.31200
Flash Point	192.2ºC
Exact Mass	274.12100
PSA	48.67000
LogP	3.31890
Index of Refraction	1.547
InChIKey	KRQHZFHWEAJPNO-UHFFFAOYSA-N
SMILES	COc1cc2oc(=O)ccc2c(OC)c1CC=C(C)C
Storage condition	2-8℃

Precursor 9
CAS#:155587-95-4 2-prenyloxy-3,4... CAS#:1099-45-2 Ethyl 2-(triphe... CAS#:19283-70-6 2-hydroxy-3,4-d... CAS#:115-18-4 2-Methyl-3-bute...
CAS#:487-70-7 2,4,6-Trihydrox... CAS#:77636-13-6 3-(3'-methyl-2'... CAS#:77636-12-5 7-acetoxy-5-met... CAS#:77636-09-0 5-hydroxy-6-(3'...
CAS#:77636-10-3 5,7-diacetoxy-6...
DownStream 0

Name: Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia co...
Source: ChEMBL
Target: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
External Id: CHEMBL3238861

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Toddaculin

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Toddaculine
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Toddaculin
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

naturewill
China
Product Name: Toddaculine
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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Toddaculine

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.