Toddaculine

Modify Date: 2025-08-21 19:33:20

Toddaculine structure	Common Name	Toddaculine
	CAS Number	4335-12-0	Molecular Weight	274.31200
	Density	1.138g/cm3	Boiling Point	432.8ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₈O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	192.2ºC

Use of Toddaculine

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

Name	5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one
Synonym	More Synonyms

Description	Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
In Vitro	Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].
References	[1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. [2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. [3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.

Density	1.138g/cm3
Boiling Point	432.8ºC at 760 mmHg
Molecular Formula	C₁₆H₁₈O₄
Molecular Weight	274.31200
Flash Point	192.2ºC
Exact Mass	274.12100
PSA	48.67000
LogP	3.31890
Index of Refraction	1.547
InChIKey	KRQHZFHWEAJPNO-UHFFFAOYSA-N
SMILES	COc1cc2oc(=O)ccc2c(OC)c1CC=C(C)C
Storage condition	2-8℃

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