(R)-Afatinib
Modify Date: 2025-08-25 19:28:40
(R)-Afatinib structure
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Common Name | (R)-Afatinib | ||
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| CAS Number | 439081-17-1 | Molecular Weight | 485.9384032 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25ClFN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R)-Afatinib(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1]. |
| Name | R-Afatinib |
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| Description | (R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C24H25ClFN5O3 |
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| Molecular Weight | 485.9384032 |