6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic

Modify Date: 2024-01-05 20:07:05

6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic Structure
6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic structure
Common Name 6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic
CAS Number 4443-26-9 Molecular Weight 261.27300
Density 1.301 g/cm3 Boiling Point 454ºC at 760 mmHg
Molecular Formula C14H15NO4 Melting Point 103-107 °C
MSDS N/A Flash Point 228.4ºC

 Use of 6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic


6-N-Phthalimidoy hexanoic acid (compound FH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-N-Phthalimidoy hexanoic acid can be combined with carrier proteins and used in antigen design[1].

 Names

Name 6-(1,3-dioxoisoindol-2-yl)hexanoic acid
Synonym More Synonyms

  Biological Activity

Description 6-N-Phthalimidoy hexanoic acid (compound FH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-N-Phthalimidoy hexanoic acid can be combined with carrier proteins and used in antigen design[1].
Related Catalog
References

[1]. Mercader JV, et al. Development of monoclonal ELISAs for azinphos-methyl. 1. Hapten synthesis and antibody production. J Agric Food Chem. 1999 Mar;47(3):1276-84.  

 Chemical & Physical Properties

Density 1.301 g/cm3
Boiling Point 454ºC at 760 mmHg
Melting Point 103-107 °C
Molecular Formula C14H15NO4
Molecular Weight 261.27300
Flash Point 228.4ºC
Exact Mass 261.10000
PSA 74.68000
LogP 1.86550
Index of Refraction 1.582

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 6-(1,3-Dioxoisoindol-2-yl)hexanoic acid
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:6-(1,3-Dioxoisoindol-2-yl)hexanoic acid
CAS number:4443-26-9

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C14H15NO4
Molecular weight:261.3

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi: Irritant;
HS Code 2925190090

 Synthetic Route

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CAS#:4443-26-9

Literature: Gademann; Kimmerlin; Hoyer; Seebach Journal of Medicinal Chemistry, 2001 , vol. 44, # 15 p. 2460 - 2468

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CAS#:4443-26-9

Literature: Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391

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CAS#:4443-26-9

Literature: Taub et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 2062 Full Text View citing articles Show Details Benson; Cairns Journal of the American Chemical Society, 1948 , vol. 70, p. 2115,2116 Org.Synth.Coll.Vol., 1963 , vol. IV, p. 588 Full Text Show Details van der Want Recueil des Travaux Chimiques des Pays-Bas, 1952 , vol. 71, p. 1012,1014

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CAS#:4443-26-9

Literature: Ohmiya, Hirohisa; Tanabe, Masahito; Sawamura, Masaya Organic Letters, 2011 , vol. 13, # 5 p. 1086 - 1088

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Literature: REPLIGEN CORPORATION Patent: US2012/94971 A1, 2012 ;

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Literature: Albert Chemische Berichte, 1909 , vol. 42, p. 549

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Literature: Albert Chemische Berichte, 1909 , vol. 42, p. 549

 Customs

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

2h-isoindole-2-hexanoic acid,1,3-dihydro-1,3-dioxo
phthalimidohexanoic acid
6-phthalimidocaproic acid
6-phthalimidohexanoic acid
Phthalimidocapronic acid
6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic