EBPC
Modify Date: 2025-09-18 22:35:31
EBPC structure
|
Common Name | EBPC | ||
|---|---|---|---|---|
| CAS Number | 4450-98-0 | Molecular Weight | 261.27 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 479.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H15NO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 244.0±28.7 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
Use of EBPCEBPC is a potent and selective aldose reductase inhibitor with an IC50 of 47 nM[1]. |
| Name | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester |
|---|---|
| Synonym | More Synonyms |
| Description | EBPC is a potent and selective aldose reductase inhibitor with an IC50 of 47 nM[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 479.8±45.0 °C at 760 mmHg |
| Molecular Formula | C14H15NO4 |
| Molecular Weight | 261.27 |
| Flash Point | 244.0±28.7 °C |
| Exact Mass | 261.100098 |
| PSA | 66.84000 |
| LogP | 1.34 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.615 |
| InChIKey | IGYRPDIWSYGHMY-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1 |
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
|
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EBPC CAS#:4450-98-0 |
| Literature: Coumar, Mohane Selvaraj; Wu, Jian-Sung; Leou, Jiun-Shyang; Tan, Uan-Kang; Chang, Chung-Yu; Chang, Teng-Yuan; Lin, Wen-Hsing; Hsu, John T.-A.; Chao, Yu-Sheng; Wu, Su-Ying; Hsieh, Hsing-Pang Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1623 - 1627 |
| Precursor 2 | |
|---|---|
| DownStream 1 | |
CAS#:53720-95-9| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions.
Front. Pharmacol. 3 , 98, (2012) Prostaglandins are important regulators of female reproductive functions to which aldose reductases exhibiting hydroxysteroid dehydrogenase activity also contribute. Our work on the regulation of repr... |
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Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.
Cell. Mol. Life Sci. 62(10) , 1146-55, (2005) Over-expression of aldose reductase (AR) has been observed in many cancer cells. To clarify the role of AR in tumor cells, we investigated the pathways mediating expression of the AR gene induced by 1... |
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
|
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Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OPM1-m4-1
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Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-OC1MY5-m4-1
|
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Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-KMS_34-m4-1
|
|
Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_L363-m4-1
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OCIMY7-m4-1
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| ethyl 1-benzyl-3-hydroxy-3-pyrrolin-2-one-4-carboxylate |
| Ethyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate |
| 1-benzyl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylic acid ethyl ester |
| 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester |
| 1-Ebpc |
| 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester CP-10668 |
| 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester |