3-Fluoro-4-nitroanisole

Modify Date: 2024-01-02 09:52:46

3-Fluoro-4-nitroanisole Structure
3-Fluoro-4-nitroanisole structure
Common Name 3-Fluoro-4-nitroanisole
CAS Number 446-38-8 Molecular Weight 171.126
Density 1.3±0.1 g/cm3 Boiling Point 264.5±20.0 °C at 760 mmHg
Molecular Formula C7H6FNO3 Melting Point 57.3ºC
MSDS Chinese USA Flash Point 113.7±21.8 °C

 Names

Name 3-Fluoro-4-nitroanisole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 264.5±20.0 °C at 760 mmHg
Melting Point 57.3ºC
Molecular Formula C7H6FNO3
Molecular Weight 171.126
Flash Point 113.7±21.8 °C
Exact Mass 171.033173
PSA 55.05000
LogP 1.82
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.522
Storage condition Keep Cold

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
3-Fluoro-4-nitroanisole
Product Name:
Synonyms:2-Fluoro-4-methoxy-1-nitrobenzene

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H314:Causes severe skin burns and eye damage
H335:May cause respiratory irritation
H412:Harmful to aquatic life with long lasting effects
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
Avoid release to the environment
P273:
P280:Wear protective gloves/protective clothing/eye protection/face protection
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P310:Immediately call a POISON CENTER or doctor/physician

Section3. Composition/information on ingredients.
3-Fluoro-4-nitroanisole
Ingredient name:
CAS number:446-38-8

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C7H6FNO3
Molecular weight:171.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN3261 Class: 8 Packing group: II
Proper shipping name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (3-Fluoro-4-nitroanisole)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 34
Safety Phrases 26-36/37/39-45
RIDADR 3261
Packaging Group
HS Code 2909309090

 Synthetic Route

~99%

3-Fluoro-4-nitroanisole Structure

3-Fluoro-4-nitr...

CAS#:446-38-8

Literature: Deiters, Emmanuel; Song, Bo; Chauvin, Anne-Sophie; Vandevyver, Caroline D. B.; Gumy, Frederic; Buenzli, Jean-Claude G. Chemistry - A European Journal, 2009 , vol. 15, # 4 p. 885 - 900

~81%

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CAS#:446-38-8

Literature: Makosza, Mieczyslaw; Lemek, Tadeusz; Kwast, Andrzej; Terrier, Francois Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 394 - 400

~97%

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CAS#:446-38-8

Literature: GLAXO GROUP LIMITED Patent: WO2006/2047 A2, 2006 ; Location in patent: Page/Page column 69 ;

~%

3-Fluoro-4-nitroanisole Structure

3-Fluoro-4-nitr...

CAS#:446-38-8

Literature: MERCK and CO., INC. Patent: WO2007/108968 A2, 2007 ; Location in patent: Page/Page column 38-39 ;

~%

3-Fluoro-4-nitroanisole Structure

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CAS#:446-38-8

Detail
Literature: Ouellet, Stephane G.; Bernardi, Anna; Angelaud, Remy; O'Shea, Paul D. Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3776 - 3779

~%

3-Fluoro-4-nitroanisole Structure

3-Fluoro-4-nitr...

CAS#:446-38-8

Literature: Kizner, T. A.; Shteingarts, V. D. Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178 Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382

~%

3-Fluoro-4-nitroanisole Structure

3-Fluoro-4-nitr...

CAS#:446-38-8

Literature: Jacquet, Jean-Pierre; Bouzard, Daniel; Cesare, Pierre Di; Dolnic, Nicolas; Massoudi, Massoud; Remuzon, Philippe Heterocycles, 1992 , vol. 34, # 12 p. 2301 - 2311

~55%

3-Fluoro-4-nitroanisole Structure

3-Fluoro-4-nitr...

CAS#:446-38-8

Literature: Purrington, Suzanne T.; Woodard, Daniel L. Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 142 - 145

~%

3-Fluoro-4-nitroanisole Structure

3-Fluoro-4-nitr...

CAS#:446-38-8

Literature: Kizner, T. A.; Shteingarts, V. D. Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2173 - 2178 Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2376 - 2382

 Customs

HS Code 2909309090
Summary 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

2-Fluoro-4-methoxy-1-nitrobenzene
3-Fluoro-4-Nitroanisole
3-Fluoro-4-nitrophenyl methyl ether
Benzene, 2-fluoro-4-methoxy-1-nitro-
WNR BF DO1