2-amino-9-(β-D-ribofuranosyl)purine

Modify Date: 2024-01-07 20:14:45

2-amino-9-(β-D-ribofuranosyl)purine Structure
2-amino-9-(β-D-ribofuranosyl)purine structure
Common Name 2-amino-9-(β-D-ribofuranosyl)purine
CAS Number 4546-54-7 Molecular Weight 267.24
Density 2.1±0.1 g/cm3 Boiling Point 711.8±70.0 °C at 760 mmHg
Molecular Formula C10H13N5O4 Melting Point 105-115ºC
MSDS N/A Flash Point 384.3±35.7 °C

 Use of 2-amino-9-(β-D-ribofuranosyl)purine


(2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-Aminopurine Riboside
Synonym More Synonyms

 2-amino-9-(β-D-ribofuranosyl)purine Biological Activity

Description (2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 711.8±70.0 °C at 760 mmHg
Melting Point 105-115ºC
Molecular Formula C10H13N5O4
Molecular Weight 267.24
Flash Point 384.3±35.7 °C
Exact Mass 267.096741
PSA 139.54000
LogP -1.40
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.907

 Safety Information

HS Code 2933599090

 Synthetic Route

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

9H-purine, 2-amino-9-β-d-ribofuranosyl-,
9-(β-D-Ribofuranosyl)-9H-purin-2-amine
9H-Purin-2-amine, 9-β-D-ribofuranosyl-
2-amino-9-(β-D-ribofuranosyl)purine
9H-Purine, 2-amino-9-β-D-ribofuranosyl-
2-(2-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol