Maculosin

Modify Date: 2024-01-05 10:11:02

Maculosin structure	Common Name	Maculosin
	CAS Number	4549-02-4	Molecular Weight	260.29
	Density	1.36g/cm3	Boiling Point	581.4ºC at 760mmHg
	Molecular Formula	C₁₄H₁₆N₂O₃	Melting Point	156-159 °C
	MSDS	N/A	Flash Point	305.4ºC

Use of Maculosin

Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC50 of 48.90 µg/mL[1][2][3].

Name	maculosin
Synonym	More Synonyms

Description	Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC50 of 48.90 µg/mL[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606. [2]. Stierle AC, et al. Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8008-11. [3]. Paudel B, et al. Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18. Pharm Biol. 2021 Dec;59(1):933-936.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.

[2]. Stierle AC, et al. Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8008-11.

[3]. Paudel B, et al. Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18. Pharm Biol. 2021 Dec;59(1):933-936.

Density	1.36g/cm3
Boiling Point	581.4ºC at 760mmHg
Melting Point	156-159 °C
Molecular Formula	C₁₄H₁₆N₂O₃
Molecular Weight	260.29
Flash Point	305.4ºC
Exact Mass	260.11600
PSA	69.64000
LogP	0.69080
Index of Refraction	1.644
Storage condition	-15°C

Hazard Codes	T+
HS Code	2933990090

N-Boc-L-Tyr-L-p...

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~84%

Maculosin

CAS#:4549-02-4

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Boc-Tyr-OH

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Maculosin

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Boc-Tyr-Pro-OBzl

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Maculosin

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L-Proline, phen...

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L-Prolinamide

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Maculosin

CAS#:4549-02-4

Literature: Milne, P. J.; Oliver, D. W.; Roos, H. M. Journal of Crystallographic and Spectroscopic Research, 1992 , vol. 22, # 6 p. 643 - 649

Boc-Tyr-Pro-OH

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Maculosin

CAS#:4549-02-4

Literature: Milne, P. J.; Oliver, D. W.; Roos, H. M. Journal of Crystallographic and Spectroscopic Research, 1992 , vol. 22, # 6 p. 643 - 649

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(3S,8aS)-3-[(4-hydroxyphenyl)methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

TYP

CYCLO-(L-TYROSINE-L-PROLINE) INHIBITOR

cyclo-L-Tyr-L-Pro

cyclo(D-Pro-D-Tyr)

(3s,8as)-3-(4-hydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

cycl(L-pro-L-tyr)

1w1y

cyclo(L-prolinyl-L-tyrosine)

(3S,8AR)-3-(4-HYDROXYBENZYL)HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE

Cyclo(L-pro-L-tyr)

Maculosin

Cyclo-(Pro-Tyr)

Maculosin

Use of Maculosin

Names

Maculosin Biological Activity

Chemical & Physical Properties

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