Neriifolin

Modify Date: 2026-07-12 08:30:38

Neriifolin structure	Common Name	Neriifolin
	CAS Number	466-07-9	Molecular Weight	534.68100
	Density	1.274g/cm3	Boiling Point	700.079ºC at 760 mmHg
	Molecular Formula	C₃₀H₄₆O₈	Melting Point	218-225ºC
	MSDS	N/A	Flash Point	224.862ºC

Use of Neriifolin

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

Name	neriifolin
Synonym	More Synonyms

Description	Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins[1].
References	[1]. Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237. [2]. Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741.

Density	1.274g/cm3
Boiling Point	700.079ºC at 760 mmHg
Melting Point	218-225ºC
Molecular Formula	C₃₀H₄₆O₈
Molecular Weight	534.68100
Flash Point	224.862ºC
Exact Mass	534.31900
PSA	114.68000
LogP	3.11020
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.581
InChIKey	VPUNMTHWNSJUOG-BAOINKAISA-N
SMILES	COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C1O

Neriifolin MSDS(Chinese)

Hazard Codes	T+
Risk Phrases	26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	FH4906100

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NERIIFOLIN

17Beta-Neriifolin

xy)-14-hydroxy

digitoxigenin+thevetose

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Shanghai Nianxing Industrial Co., Ltd
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Purity: 98.0%
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China
Product Name: Neriifolin
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Purity: 98.0%
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Contact: Bella
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Neriifolin

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