Cinobufagin structure
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Common Name | Cinobufagin | ||
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CAS Number | 470-37-1 | Molecular Weight | 442.545 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 595.4±50.0 °C at 760 mmHg | |
Molecular Formula | C26H34O6 | Melting Point | 222-223ºC | |
MSDS | Chinese USA | Flash Point | 199.4±23.6 °C | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of CinobufaginCinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer.IC50 value:Target:In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2].In vivo: |
Name | Cinobufagin |
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Synonym | More Synonyms |
Description | Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer.IC50 value:Target:In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2].In vivo: |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 595.4±50.0 °C at 760 mmHg |
Melting Point | 222-223ºC |
Molecular Formula | C26H34O6 |
Molecular Weight | 442.545 |
Flash Point | 199.4±23.6 °C |
Exact Mass | 442.235535 |
PSA | 89.27000 |
LogP | 2.43 |
Vapour Pressure | 0.0±3.8 mmHg at 25°C |
Index of Refraction | 1.595 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H300-H310-H330 |
Precautionary Statements | P260-P264-P280-P284-P302 + P350-P310 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | T+: Very toxic; |
Risk Phrases | R26/27/28 |
Safety Phrases | S22-S36/37/39-S45 |
RIDADR | UN 2811 |
WGK Germany | 3 |
RTECS | GD7850000 |
Packaging Group | II |
Hazard Class | 6.1(a) |
HS Code | 3001200090 |
Precursor 0 | |
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DownStream 1 | |
HS Code | 3001200090 |
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Microbial transformation of cinobufagin by Syncephalastrum racemosum.
J. Nat. Prod. 71 , 1268-70, (2008) Microbial transformation of a cytotoxic bufadienolide, cinobufagin (1), was performed by Syncephalastrum racemosum. The six metabolites obtained were identified as 7beta-hydroxycinobufagin ( 2), 12bet... |
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Preparative separation of four major bufadienolides from the Chinese traditional medicine, Chansu, using high-speed counter-current chromatography.
Nat. Prod. Commun. 5(7) , 1031-4, (2010) A preparative, high-speed, counter-current chromatographic (HSCCC) method for the isolation and purification of bufadienolides from Chansu was successfully developed by using stepwise elution with a t... |
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Cinobufacini induced MDA-MB-231 cell apoptosis-associated cell cycle arrest and cytoskeleton function.
Bioorg. Med. Chem. Lett. 22(3) , 1459-63, (2012) Cinobufacini is a traditional Chinese anti-tumor drug and widely used in clinic experiences. But little is known about its effect on the cells. In this study, the effects of cinobufacini on breast can... |
Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)- |
(3β,5β,15β,16β)-16-Acetoxy-3-hydroxy-14,15-epoxybufa-20,22-dienolide |
5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,16β-dihydroxy-, 16-acetate (8CI) |
cinobufagine |
Bufa-20,22-dienolide, 16- (acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)- |
CINOBUFAGIN(P) |
UNII:T9PSN4R8IR |
5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,16β-dihydroxy-, 16-acetate |
MFCD00056825 |
RARECHEM BK HC T302 |
Cinobufagin |
(3β,5β,15β,16β)-16-(acetyloxy)-3-hydroxy-14,15-epoxybufa-20,22-dienolide |