Ruscogenin

Modify Date: 2024-01-02 18:04:25

Ruscogenin structure	Common Name	Ruscogenin
	CAS Number	472-11-7	Molecular Weight	430.62
	Density	1.2±0.1 g/cm3	Boiling Point	563.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₂O₄	Melting Point	198-202ºC
	MSDS	Chinese USA	Flash Point	294.4±30.1 °C

Use of Ruscogenin

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].

Name	Ruscogenin
Synonym	More Synonyms

Description	Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
References	[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. [2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

References

[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418.

[2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

Density	1.2±0.1 g/cm3
Boiling Point	563.1±50.0 °C at 760 mmHg
Melting Point	198-202ºC
Molecular Formula	C₂₇H₄₂O₄
Molecular Weight	430.62
Flash Point	294.4±30.1 °C
Exact Mass	430.308319
PSA	58.92000
LogP	4.29
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.577
Storage condition	2~8℃