(+)-brazilin

Modify Date: 2025-08-22 16:47:26

(+)-brazilin structure	Common Name	(+)-brazilin
	CAS Number	474-07-7	Molecular Weight	286.279
	Density	1.6±0.1 g/cm3	Boiling Point	555.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₄O₅	Melting Point	156-157ºC
	MSDS	N/A	Flash Point	289.9±30.1 °C

Use of (+)-brazilin

Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities[1][2][3].

Name	brazilin
Synonym	More Synonyms

Description	Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
References	[1]. Dapson RW, et al. Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. Biotech Histochem. 2015;90(6):401-23. [2]. Jia Y, et al. [Effect of brazilin on apoptosis and autophagy of tongue cancer Tca8113 cells and its molecular mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 Mar 30;39(3):351-356. [3]. Weinmann D, et al, Brazilin blocks catabolic processes in human osteoarthritic chondrocytes via inhibition of NFKB1/p50. J Orthop Res. 2018 Sep;36(9):2431-2438.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

References

[1]. Dapson RW, et al. Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. Biotech Histochem. 2015;90(6):401-23.

[2]. Jia Y, et al. [Effect of brazilin on apoptosis and autophagy of tongue cancer Tca8113 cells and its molecular mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 Mar 30;39(3):351-356.

[3]. Weinmann D, et al, Brazilin blocks catabolic processes in human osteoarthritic chondrocytes via inhibition of NFKB1/p50. J Orthop Res. 2018 Sep;36(9):2431-2438.

Density	1.6±0.1 g/cm3
Boiling Point	555.8±50.0 °C at 760 mmHg
Melting Point	156-157ºC
Molecular Formula	C₁₆H₁₄O₅
Molecular Weight	286.279
Flash Point	289.9±30.1 °C
Exact Mass	286.084137
PSA	90.15000
LogP	1.32
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.774
InChIKey	UWHUTZOCTZJUKC-JKSUJKDBSA-N
SMILES	Oc1ccc2c(c1)OCC1(O)Cc3cc(O)c(O)cc3C21

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE3124000

CHEMICAL NAME :: Benz(b)indeno(1,2-d)pyran-3,6a,9,10(6H)-tetrol, 7,11b-dihydro-

CAS REGISTRY NUMBER :: 474-07-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H14-O5

MOLECULAR WEIGHT :: 286.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),252,1982

Hazard Codes	Xi
Safety Phrases	24/25

Name: Cytotoxicity against rat PC12 cells assessed as survival rate at 50 to 100 uM incubat...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5518532

Name: Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytocha...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1064992

Name: Cytotoxicity against rat PC12 cells assessed as survival rate at 100 uM incubated for...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5518531

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS

Name: Cytotoxicity against rat PC12 cells assessed as survival rate at 50 uM incubated for ...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5518530

Name: Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytocha...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1064990

Name: Cytotoxicity against rat PC12 cells assessed as survival rate at 25 uM incubated for ...
Source: ChEMBL
Target: PC-12
External Id: CHEMBL5518529

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491

Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

Total 32, Current Page 1 of 4

(6aS-cis)-7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol

superbresiline

pernambucoextract

(+)-brazilin

(6aS,11bR)-7,11b-Dihydroindeno[2,1-c]chromene-3,6a,9,10(6H)-tetrol

braziletto

C.I. Natural Red 24

hypernicextract

limawoodextract

BRAZILIN

brasilin

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (+)-brazilin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Brazilin
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (+)-brazilin
Price: ￥1058.0/20mg ￥938.0/10mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

naturewill
China
Product Name: (+)-brazilin
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

Get all suppliers and price by the below link:

(+)-brazilin suppliers

(+)-brazilin price

(+)-brazilin

Use of (+)-brazilin

Names

(+)-brazilin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

(+)-brazilinBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.