Daucosterol

Modify Date: 2024-01-02 09:22:10

Daucosterol Structure
Daucosterol structure
 Common Name Daucosterol
CAS Number 474-58-8 Molecular Weight 576.847
Density 1.1±0.1 g/cm3 Boiling Point 673.6±55.0 °C at 760 mmHg
Molecular Formula C35H60O6 Melting Point N/A
MSDS Chinese USA Flash Point 361.2±31.5 °C

 Use of Daucosterol


Daucosterol is a natural sterolin. IC50 value:Target:In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3].In vivo:

 Names

Name Daucosterol
Synonym More Synonyms

 Daucosterol Biological Activity

Description Daucosterol is a natural sterolin. IC50 value:Target:In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3].In vivo:
Related Catalog
References

[1]. Jiang LH, et al. Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway. J Steroid Biochem Mol Biol. 2015 Aug;152:45-52.

[2]. Jiang LH, et al. Daucosterol promotes the proliferation of neural stem cells. J Steroid Biochem Mol Biol. 2014 Mar;140:90-9.

[3]. Zhao C, et al. Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner. Life Sci. 2015 Sep 15;137:37-43.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 673.6±55.0 °C at 760 mmHg
Molecular Formula C35H60O6
Molecular Weight 576.847
Flash Point 361.2±31.5 °C
Exact Mass 576.438965
PSA 99.38000
LogP 8.78
Vapour Pressure 0.0±4.7 mmHg at 25°C
Index of Refraction 1.554
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WJ2508000
CHEMICAL NAME :
Stigmast-5-ene, 3-beta-(beta-D-glucopyranosyloxy)-
CAS REGISTRY NUMBER :
474-58-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C35-H60-O6
MOLECULAR WEIGHT :
576.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78. For publisher information, see IJSIDW. Volume(issue)/page/year: 29,91,1967

 Safety Information

Safety Phrases 24/25
RIDADR NONH for all modes of transport
HS Code 29389090

 Synthetic Route

 Articles26

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 Synonyms

β-D-Glucopyranoside, (3β)-stigmast-5-en-3-yl
Daucosterin
lyoniside
Coriandrinol
(3b)-Stigmast-5-en-3-yl b-D-Glucopyranoside
Sitogluside
β-Sitosterol β-D-glucoside
β-sitosterol-D-glucoside
b-Daucosterol
b-Sitosteryl glucoside
Alexandrin
Eleutheroside A
β-sitosterol 3-O-β-D-glucopyranoside
1513DMIa
Sterolin
β-sitosteryl-β-D-glucopyranoside
3b-(b-D-glucopyranosyloxy)stigmast-5-ene
Doursterol
(3β)-Stigmast-5-en-3-yl β-D-glucopyranoside
3β-(β-D-Glucopyranosyloxy)stigmast-5-ene
Stigmast-5-ene, 3-β-(β-D-glucopyranosyloxy)-
BSSG
β-Sitosteryl glucoside
3-β-D-glucosylsitosterol
3-β-(β-D-Glucopyranosyloxy)stigmast-5-ene
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