Glycocholic acid
Modify Date: 2024-01-02 15:10:48
Glycocholic acid structure
|
Common Name | Glycocholic acid | ||
|---|---|---|---|---|
| CAS Number | 475-31-0 | Molecular Weight | 465.623 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 655.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C26H43NO6 | Melting Point | 128°C | |
| MSDS | N/A | Flash Point | 350.1±34.3 °C | |
Use of Glycocholic acidGlycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. |
| Name | glycocholic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite Bax Bcl-2 MDR1 MRP1 MDR2 |
| In Vitro | Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 655.3±65.0 °C at 760 mmHg |
| Melting Point | 128°C |
| Molecular Formula | C26H43NO6 |
| Molecular Weight | 465.623 |
| Flash Point | 350.1±34.3 °C |
| Exact Mass | 465.309052 |
| PSA | 127.09000 |
| LogP | 2.45 |
| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
| Index of Refraction | 1.645 |
| Storage condition | Refrigerator |
| Water Solubility | methanol: 0.1 g/mL, clear, colorless |
| Hazard Codes | N:Dangerousfortheenvironment; |
|---|---|
| Risk Phrases | R51/53 |
| Safety Phrases | S61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| Precursor 0 | |
|---|---|
| DownStream 3 | |
CAS#:621-79-4![ethyl N-[3-phenyl-1-oxo-2-propen-1-yl] glycinate structure](https://www.chemsrc.com/caspic/018/62430-51-7.png)
CAS#:62430-51-7
CAS#:56-40-6| (Z)-N-[(3α,5β,7α,8ξ,12α,20R,24Z)-3,7,12,24-Tetrahydroxycholan-24-ylidene]glycine |
| Glycine, N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]- |
| N-choloyl-Glycine |
| Glycocholic Acid Hydrate |
| 3a,7a,12a-Trihydroxy-5b-cholan-24-oylglycine |
| Glycocholic acid |
| Glycine, N-[(3α,5β,7α,8ξ,12α,20R,24Z)-3,7,12,24-tetrahydroxycholan-24-ylidene]-, (Z)- |
| N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine |
| 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid |
| N-Choloylglycine |
| N-[(3a,5b,7a,12a)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine |
| EINECS 207-494-9 |
| ({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)acetic acid |
| MFCD06408004 |
| Glycine, N-((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)- |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Glycocholic acid
- Price: ￥66.0/1g ￥1096.0/25g ￥506.0/10g ￥276.0/5g
- Purity: 97.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Glycocholic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Glycocholic acid
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: ￥550/10 mM * 1 mL in DMSO
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