PHA-543613 dihydrochloride
Modify Date: 2024-01-03 19:46:51
PHA-543613 dihydrochloride structure
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Common Name | PHA-543613 dihydrochloride | ||
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| CAS Number | 478148-58-2 | Molecular Weight | 344.23600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H19Cl2N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PHA-543613 dihydrochloridePHA-543613 dihydrochloride is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki value of 8.8 nM. PHA-543613 dihydrochloride displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 dihydrochloride can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2][3]. |
| Name | PHA-543613 Dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | PHA-543613 dihydrochloride is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki value of 8.8 nM. PHA-543613 dihydrochloride displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 dihydrochloride can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2][3]. |
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| Related Catalog | |
| Target |
Ki: 8.8 nM (α7 nAChR)[1] |
| In Vivo | PHA-543613 dihydrochloride (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats[2]. PHA-543613 dihydrochloride (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema is dependent on the PI3K-Akt signaling pathway[3]. Animal Model: Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery[3] Dosage: 4 and 12 mg/kg Administration: Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery Result: Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits andbrain edema at 72 hours after ICH. |
| Molecular Formula | C15H19Cl2N3O2 |
|---|---|
| Molecular Weight | 344.23600 |
| Exact Mass | 343.08500 |
| PSA | 58.37000 |
| LogP | 3.58460 |
| N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide |