PHA-408
Modify Date: 2025-08-25 16:53:33
PHA-408 structure
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Common Name | PHA-408 | ||
|---|---|---|---|---|
| CAS Number | 503555-55-3 | Molecular Weight | 560.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H27ClFN7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PHA-408PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1]. |
| Name | 8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1]. |
|---|---|
| Related Catalog | |
| Target |
IKK-2 |
| References |
| Molecular Formula | C29H27ClFN7O2 |
|---|---|
| Molecular Weight | 560.02 |
| Exact Mass | 559.19000 |
| PSA | 113.86000 |
| LogP | 5.19950 |
![8-amino-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide structure](https://image.chemsrc.com/caspic/228/503555-51-9.png)
![(+/-)-1-(tert-butyl)-4,4-dimethyl-1-[(triisopropylsilyl)ethynyl]pent-2-ynyl methyl carbonate structure](https://image.chemsrc.com/caspic/028/503555-56-4.png)
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| pha-408 |