TC OT 39

Modify Date: 2025-10-15 12:32:18

TC OT 39 structure	Common Name	TC OT 39
	CAS Number	479232-57-0	Molecular Weight	600.777
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₂H₄₀N₈O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TC OT 39

TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models[1].

Name	TC OT 39
Synonym	More Synonyms

Description	TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor Research Areas >> Neurological Disease
Target	Avprla vasopressin receptor:300 nM (Ki) Oxytocin Receptor:180 nM (EC50)
In Vivo	TC OT 39 (50 mg/kg、75 mg/kg；腹腔注射；在 8-9 天内注射 4 次)，在 50 mg/kg 的剂量下，显著减少 C57BL/6J 小鼠的大理石掩埋行为，并在 75 mg/kg 的剂量下显示出明显的镇静作用[1]。大理石掩埋是基于啮齿动物掩埋物体的自然本能，常用于临床前研究以评估啮齿动物的焦虑样行为[1]。
References	[1]. Moy SS, et al. Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism. Neuropharmacology. 2019 Jan;144:301-311.

Density	1.4±0.1 g/cm3
Molecular Formula	C₃₂H₄₀N₈O₂S
Molecular Weight	600.777
Exact Mass	600.299500
LogP	2.00
Index of Refraction	1.702
InChIKey	KSNHHKZYKYNBEI-NDEPHWFRSA-N
SMILES	Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCCC1C(=S)N1CCCN(C)CC1

(2S)-2-[(4-Methyl-1,4-diazepan-1-yl)carbonothioyl]-N-{2-methyl-4-[(1-methyl-4,10-dihydropyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]benzyl}-1-pyrrolidinecarboxamide

(2S)-2-[(4-methyl-1,4-diazepan-1-yl)carbothioyl]-N-{2-methyl-4-[(1-methyl-4,10-dihydropyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]benzyl}pyrrolidine-1-carboxamide

1-Pyrrolidinecarboxamide, N-[[4-[(4,10-dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-, (2S)-

MFCD28133368

TC OT 39

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TC OT 39

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.