Lecanoricacid

Modify Date: 2026-07-13 17:52:58

Lecanoricacid Structure
Lecanoricacid structure
Common Name Lecanoricacid
CAS Number 480-56-8 Molecular Weight 318.278
Density 1.5±0.1 g/cm3 Boiling Point 557.1±50.0 °C at 760 mmHg
Molecular Formula C16H14O7 Melting Point 175-176ºC
MSDS N/A Flash Point 208.3±23.6 °C

 Use of Lecanoricacid


Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase[1].

 Names

Name o-orsellinate depside
Synonym More Synonyms

 Lecanoricacid Biological Activity

Description Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase[1].
Related Catalog
References

[1]. Umezawa H, et al. Isolation of lecanoric acid, an inhibitor of histidine decarboxylase from a fungus. J Antibiot (Tokyo). 1974;27(8):587-596.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 557.1±50.0 °C at 760 mmHg
Melting Point 175-176ºC
Molecular Formula C16H14O7
Molecular Weight 318.278
Flash Point 208.3±23.6 °C
Exact Mass 318.073944
PSA 124.29000
LogP 4.39
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.675
InChIKey HEMSJKZDHNSSEW-UHFFFAOYSA-N
SMILES Cc1cc(OC(=O)c2c(C)cc(O)cc2O)cc(O)c1C(=O)O

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH3709950
CHEMICAL NAME :
beta-Resorcylic acid, 6-methyl-, 4-(6-methyl-beta-resorcylate)
CAS REGISTRY NUMBER :
480-56-8
BEILSTEIN REFERENCE NO. :
2172778
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H14-O7
MOLECULAR WEIGHT :
318.30
WISWESSER LINE NOTATION :
QVR BQ F1 DOVR DQ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,587,1974

 Safety Information

Hazard Codes Xi

 LecanoricacidBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary
Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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 Synonyms

4-[(2,4-Dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoic acid
4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
o-orsellinate depside
lecanoric aicd
Lecanoric acid
lecanolic acid
2,4-Dihydroxy-6-methylbenzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester
Lecanoricacid
Lecanorsaeure
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