Cepharanthine
Cepharanthine structure
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Common Name | Cepharanthine | ||
|---|---|---|---|---|
| CAS Number | 481-49-2 | Molecular Weight | 606.707 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C37H38N2O6 | Melting Point | 140 - 145ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CepharanthineCepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities[1][2][3]. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R)[3]. Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells[4]. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity[5]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Cepharanthine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Cepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities[1][2][3]. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R)[3]. Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells[4]. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity[5]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Melting Point | 140 - 145ºC |
| Molecular Formula | C37H38N2O6 |
| Molecular Weight | 606.707 |
| Exact Mass | 606.273010 |
| PSA | 61.86000 |
| LogP | 5.23 |
| Index of Refraction | 1.608 |
| InChIKey | YVPXVXANRNDGTA-WDYNHAJCSA-N |
| SMILES | COc1ccc2cc1Oc1ccc(cc1)CC1c3c(cc4c(c3Oc3cc5c(cc3OC)CCN(C)C5C2)OCO4)CCN1C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | T+ |
| RIDADR | NONH for all modes of transport |
| RTECS | FK0527000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists relevant public references with title, journal and publication metadata for this compound.
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Interaction of cepharanthine with immobilized heat shock protein 90α (Hsp90α) and screening of Hsp90α inhibitors.
Anal. Biochem. 434(1) , 202-6, (2013) Heat shock protein 90α (Hsp90α) immobilized on aminopropyl silica gels was prepared via the N- or C-terminal, which was termed Hsp90α-NT or Hsp90α-CT, respectively. Binding interactions of biscoclauri... |
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Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity.
Bioorg. Med. Chem. Lett. 24(9) , 2115-7, (2014) The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-depende... |
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Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs.
Chin. J. Cancer 33(5) , 223-30, (2014) ABCC10, also known as multidrug-resistant protein 7 (MRP7), is the tenth member of the C subfamily of the ATP-binding cassette (ABC) superfamily. ABCC10 mediates multidrug resistance (MDR) in cancer c... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| O-Methylcepharanoline |
| (14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2.1.1.0.0.0]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dod ecaene |
| 6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis-(oxy)]oxyacanthan |
| CEPHARANTHINE (RG) |
| (+)-cepharanthine |
| [methylenebis(oxy)] |
| Cepharanthine |
| sepharanthine |
| Cepharantin |
| CEPHARANTHINUM |
| (14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2.1.1.0.0.0]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene |
| 6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]oxyacanthan |
| 6,7-methanediyldioxy-6',12'-dimethoxy-2,2'-dimethyl-oxyacanthane |
| Stephanotis |
| Cepharanthin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of Cepharanthine? |
| A: InChIKey of Cepharanthine is YVPXVXANRNDGTA-WDYNHAJCSA-N. |
| Q: What is the polar surface area (PSA) of Cepharanthine? |
| A: Polar surface area (PSA) of Cepharanthine is 61.86000. |
| Q: What is the molecular weight of Cepharanthine? |
| A: Molecular weight of Cepharanthine is 606.707. |
| Q: What is the SMILES notation of Cepharanthine? |
| A: SMILES notation of Cepharanthine is COc1ccc2cc1Oc1ccc(cc1)CC1c3c(cc4c(c3Oc3cc5c(cc3OC)CCN(C)C5C2)OCO4)CCN1C. |
| Q: What is the LogP of Cepharanthine? |
| A: LogP of Cepharanthine is 5.23. |
| Q: What are the uses of Cepharanthine? |
| A: Main uses of Cepharanthine: Cepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities[1][2][3]. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R)[3]. Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells[4]. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity[5]. |
| Q: What is the English name of Cepharanthine? |
| A: The English name of Cepharanthine is Cepharanthine. |
| Q: What is the CAS number of Cepharanthine? |
| A: CAS number of Cepharanthine is 481-49-2. |
| Q: What is the molecular formula of Cepharanthine? |
| A: Molecular formula of Cepharanthine is C37H38N2O6. |
| Q: What is the melting point of Cepharanthine? |
| A: Melting point of Cepharanthine is 140 - 145ºC. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |